ID A0A3Q1MZA1_BOVIN Unreviewed; 653 AA.
AC A0A3Q1MZA1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Scm polycomb group protein homolog 1 {ECO:0000313|Ensembl:ENSBTAP00000061499.1};
GN Name=SCMH1 {ECO:0000313|Ensembl:ENSBTAP00000061499.1,
GN ECO:0000313|VGNC:VGNC:34340};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000061499.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000061499.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061499.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000061499.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061499.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SCM family. {ECO:0000256|ARBA:ARBA00008469}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010801996.1; XM_010803694.2.
DR AlphaFoldDB; A0A3Q1MZA1; -.
DR Ensembl; ENSBTAT00000066775.1; ENSBTAP00000061499.1; ENSBTAG00000001629.6.
DR VEuPathDB; HostDB:ENSBTAG00000001629; -.
DR VGNC; VGNC:34340; SCMH1.
DR GeneTree; ENSGT00940000157999; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000001629; Expressed in spermatid and 108 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MZA1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20105; MBT_SCMH1_rpt1; 1.
DR CDD; cd20108; MBT_SCMH1_rpt2; 1.
DR CDD; cd09578; SAM_Scm; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047279; MBT_SCMH1_rpt1.
DR InterPro; IPR047280; MBT_SCMH1_rpt2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR047531; SAM_Scm-like.
DR InterPro; IPR033763; SCML2_RBR.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF68; POLYCOMB PROTEIN SCMH1; 1.
DR Pfam; PF02820; MBT; 2.
DR Pfam; PF17208; RBR; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 2.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51079; MBT; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT REPEAT 42..140
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 148..249
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 586..651
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 247..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 72728 MW; 846F5A9A24AC7A25 CRC64;
MQKSDPRKVI DWNDVRKHKY GHLSESASQH QEATDILELG HFTWDKYLKE TCSVPAPIHC
FKQSYTPPSN EFKISMKLEA QDPRNTTSTC IATVVGLTGA RLRLRLDGSD NKNDFWRLVD
SAEIQPIGNC EKNGGMLQPP LGFRLNASSW PMFLLKTLNG AEMAPIRIFH KEPPSPSHNF
FKMGMKLEAV DRKNPHFICP ATIGEVRGSE VLVTFDGWRG AFDYWCRFDS RDIFPVGWCS
LTGDNLQPPG TKVVIPKNPY PASDVNTEKP SIHSSTKTVL EHQPGQRGRK PGKKRGRTPK
PLIPHPISTP SKSAEPLKFP KKRGPKPGSK RKPRTLLNPP PTSPTTSTPE PDTSTVPQDA
ATIPSSAIQA PTVCIYLNKN GSTGPHLDKK KVQQLPDHFG PARASMVLQQ AVQACIDCAY
HQKTVFSFLK QGHGGAVISA VFDREQHTLN LPAVNSITYV LRFLEKLCHN LRSDNLFGNQ
PFTQTHLSLS TTEYSHSHDR YLPGETFALG NSLARSLEPH SDSMDSTLNP TNLVSTSQNL
RNPGYRPLLP SCGLPLSTAS AVRRLCSRGS DRRDASRLSG RDPSSWTVED VMQFVREADP
QFGPHADLFR KHEIDGKALL LLRSDTMMKY MGLKLGPALK LCYHIDRLKQ GKF
//
