ID A0A3Q1MZD9_BOVIN Unreviewed; 1094 AA.
AC A0A3Q1MZD9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=RB transcriptional corepressor like 2 {ECO:0000313|Ensembl:ENSBTAP00000061570.1};
GN Name=RBL2 {ECO:0000313|Ensembl:ENSBTAP00000061570.1,
GN ECO:0000313|VGNC:VGNC:33782};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000061570.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000061570.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061570.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000061570.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061570.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR AlphaFoldDB; A0A3Q1MZD9; -.
DR Ensembl; ENSBTAT00000075832.1; ENSBTAP00000061570.1; ENSBTAG00000016243.6.
DR VEuPathDB; HostDB:ENSBTAG00000016243; -.
DR VGNC; VGNC:33782; RBL2.
DR GeneTree; ENSGT00950000183202; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000016243; Expressed in abdominal lymph node and 109 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MZD9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20606; CYCLIN_RBL2; 1.
DR CDD; cd00043; CYCLIN_SF; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 4.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF8; RETINOBLASTOMA-LIKE PROTEIN 2; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 3.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 47..134
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 97..239
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 417..563
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 803..889
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 978..1094
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 122872 MW; 0E0885BBE447445C CRC64;
MPSGGDQSPP PPPPPPAAAA SDEEEEDDGE AEDAAQPSRS PAPQTQQRFD ELCSRLNMDE
AARAEAWESY RSMSESYTLE GNDLHWLACA LYVACRKSVP TVSKGTVEGN YVSLTRILRC
SEQSLIEFFN KMKKWEDMAN LPPHFRERTE RLERNFTVSA VIFKKYEPIF QDIFKYPQEE
QPRQQRGRKQ RRQPCTVSEV FHFCWVLFIY AKGNFPMISD DLVNSYHLLL CALDLVYGNA
LQCSNRKELV NPNFKGLSED FHAKDSKPSS DPPCVIEKLC SLHDGLVLEA KGIKEHFWKP
YIRKLYEKKL LKGKEENLTG FLEPGNFGES FKAINKAYEE YVLSVGNLDE RIFLGEDAEE
EIGTLSRCLN TGSGAETAER VQMKNILQQH FDKSKALRVS TPLTGVRYIK DSSPCVTPVS
TATHSLSRLH TMLTGLRNAP SERLEQTLRS CSRDPTQAIA NRLKEMYEIY SQHFQSEEDG
SNCAKDIASK HFRFAEMLYY KVLESVIEQE QKRLGDMDLS VIEVFIRAED GLCREVVKHL
NQIEEQILDH LAWKPESPLW DRIRDNENRV PTCEEVMPPQ NLERADEICI AGSPLTPRRV
SEVRADSGGL GRSISSPTTL YDRYSSPTAS STRRRLFVEN DSPTDGGTPG RTPPQPLVNA
VPVQNVAGEA VSVTPVPGQT LVTMATATVT ANNGQTVTIP VQGIANENGG ITFFPVQVNV
GGQAQAVTGS IQPLSAQALA GSLSSQQVTG TTLQVPGQVA IQQISPGGPQ QKQGLPLTSS
SIRPRKTSSL SLFFRKVYHL AGVRLRDLCA KLDISDELRK KIWTCFEFSI IQCPELMMDR
HLDQLLMCAI YVMAKVTKED KSFQNIMRCY RTQPQARSQV YRSVLIKGKR RRRNSGSSDS
RSHQNSPTEL NKDRTSRDSS PVMRSSSTLP VPQPSSAPPT PTRLTGANSD VEEEERGDLI
QFYNNIYIRQ MKTFAMKYSQ ANAMDAPPLS PYPFVRTGSP RRIQLSQNHP VYISPHKNEA
MLSPREKIFY YFSNSPSKRL REINSMIRTG ETPTKKRGIL LEDGSESPAK RICPENHSAL
LRRLQDVAND RGSH
//
