ID A0A3Q1N0T8_BOVIN Unreviewed; 1162 AA.
AC A0A3Q1N0T8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DAB2 interacting protein {ECO:0000313|Ensembl:ENSBTAP00000062387.1};
GN Name=DAB2IP {ECO:0000313|Ensembl:ENSBTAP00000062387.1,
GN ECO:0000313|VGNC:VGNC:27866};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000062387.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000062387.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000062387.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000062387.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000062387.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1N0T8; -.
DR Ensembl; ENSBTAT00000071113.1; ENSBTAP00000062387.1; ENSBTAG00000008232.6.
DR VEuPathDB; HostDB:ENSBTAG00000008232; -.
DR VGNC; VGNC:27866; DAB2IP.
DR GeneTree; ENSGT00940000155853; -.
DR ChiTaRS; DAB2IP; cattle.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000008232; Expressed in vas deferens and 104 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1N0T8; baseline and differential.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd13376; PH_DAB2IP; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1162
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018698090"
FT DOMAIN 165..199
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 190..308
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 368..560
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 35..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1017..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..937
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1036
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 127330 MW; D29D94517AD6D308 CRC64;
MGAGGAASHS LAWASLPLLG PPAGALCEDT LCCRESPQER PGSRRSLPGS LSEKSPSMEP
SATTPFRVTG FLSRRLKGSI KRTKSQPKLD RNHSFRHILP GFRSAAAAAA ASAADNERSH
LMPRLKESRS HESLLSPSSA VEALDLSMEE EVVIKPVHSS ILGQDYCFEV TTSSGSKCFS
CRSAAERDKW MENLRRAVHP NKDNSRRVEH ILKLWVIEAK DLPAKKKYLC ELCLDDVLYA
RTTGKLKTDN VFWGEHFEFH NLPPLRMVTV HLYRETDKKK KKERSSYLGL VSLPAASVAG
RQFVEKWYPV VTPNPKGGKG PGPMIRIKAR YQTITILPME MYKEFAEHIT NHYLGLCAAL
EPILSAKTKE EMASALVHIL QSTGKVKDFL TDLMMSEVDR CGDNEHLIFR ENTLATKAIE
EYLKLVGQKY LQDALGEFIK ALYESDENCE VDPSKCSAAD LPEHQGNLKM CCELAFCKII
NSYCVFPREL KEVFASWRQE CSSRGRPDIS ERLISASLFL RFLCPAIMSP SLFNLLQEYP
DDRTARTLTL IAKVTQNLAN FAKFGSKEEY MSFMNQFLEH EWTNMQRFLL EISNPETVSN
TAGFEGYIDL GRELSSLHSL LWEAVSQLEQ SIVSKLGPLP RILRDVHTAL STPGSGQLAG
TNDLASTPGS GSSSVSAGLQ KMVIENDLSG LIDFTRLPSP TPENKDLFFV TRSSGVQPSP
ARSSSYSEAN EPDLQMANGG KSLSMVDLQD ARVLDGEAGS PAGPDALTAD GQAPATQLVA
GWPARAAPVS LAGLATVRRA GQTPTTPGTS EGAPGRPQLL APLSFQNPVY QMAAGLPLSP
RGLGDSGSEG HSSLSSHSNS EELAAATKLG SFSSSTAAAA PEDLGRRPGE LARRQVSLTE
KGGQPTVPRQ NSAGPQRRID QPPPPPPPPP PAPRGRTPPT LLSTLQYPRP SSGTLASASP
DWAGPGARLR QQSSSSKGDS PELKPRAVHK QGPSPVSPNA LDRTAAWLLT MNAQLLEDEG
LGPDPPHRDR LRSKEELSQA EKDLAVLQDK LRISTKKLEE YETLFKCQEE TTQKLVLEYQ
ARLEEGEERL RRQQEDKDIQ MKGIISRLMS VEEELKKDHA EMQAAVDSKQ KIIDAQEKRI
ASLDAANARL MSALTQLKES MH
//
