ID A0A3Q1N2K1_BOVIN Unreviewed; 459 AA.
AC A0A3Q1N2K1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Islet cell autoantigen 1 {ECO:0000313|Ensembl:ENSBTAP00000063518.1};
GN Name=ICA1 {ECO:0000313|Ensembl:ENSBTAP00000063518.1,
GN ECO:0000313|VGNC:VGNC:30023};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000063518.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000063518.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063518.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000063518.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063518.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1N2K1; -.
DR Ensembl; ENSBTAT00000074033.1; ENSBTAP00000063518.1; ENSBTAG00000000799.5.
DR VEuPathDB; HostDB:ENSBTAG00000000799; -.
DR VGNC; VGNC:30023; ICA1.
DR GeneTree; ENSGT00390000005530; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000000799; Expressed in semen and 105 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1N2K1; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR CDD; cd07661; BAR_ICA69; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR010504; AH_dom.
DR InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like.
DR InterPro; IPR006723; Islet_autoAg_Ica1_C.
DR PANTHER; PTHR10164; ISLET CELL AUTOANTIGEN 1; 1.
DR PANTHER; PTHR10164:SF3; ISLET CELL AUTOANTIGEN 1; 1.
DR Pfam; PF06456; Arfaptin; 1.
DR Pfam; PF04629; ICA69; 2.
DR SMART; SM01015; Arfaptin; 1.
DR SMART; SM01237; ICA69; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS50870; AH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 51..254
FT /note="AH"
FT /evidence="ECO:0000259|PROSITE:PS50870"
FT REGION 288..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 52321 MW; C468DDE92CDB4495 CRC64;
MPVPFSSYPW DLHNRYPQDK SVVNKMQQKY WETKQAFIKA TGKKEDEHVV ASDADLDAKL
ELFHSIQRTC LDLSKAIVLY QKRICFLSQE ENELGKFLRS QGFQDKTRAG KMMQATGKAL
CFSSQQRLAL RNPLCRFHQE VETFRHRAIS DTWLTVNRME QCRTEYRGAL LWMKDVSQEL
DPDLCKQMEK FRKVQTQVRL AKKSFDKLKM DVCQKVDLLG ASRCNLLSHM LATYQTTLLH
FWEKTSHTMA AIHESFRGYQ PYEFTTLKSL QDPMRKLVEK EEKKRIAQQE SAEAVAEEPS
QLISLEDENQ HKESSSFKNE LLDMKPEEGA CLGPMAGTPE PEGADKDDLL LLSEIFNASS
LEEGEFSKEW AAVFGDGRLK EPMPTAAPGE LDPRPQAGSG FLPSQLLDQN IKDLQASLEE
PAKASSDLTA WFSLFADLDP LSNPDAIGKT DKEHELLNA
//
