ID A0A3Q1N6R9_BOVIN Unreviewed; 552 AA.
AC A0A3Q1N6R9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Adenosine deaminase domain containing 2 {ECO:0000313|Ensembl:ENSBTAP00000066238.1};
GN Name=ADAD2 {ECO:0000313|Ensembl:ENSBTAP00000066238.1,
GN ECO:0000313|VGNC:VGNC:25602};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000066238.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000066238.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066238.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000066238.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066238.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1N6R9; -.
DR SMR; A0A3Q1N6R9; -.
DR STRING; 9913.ENSBTAP00000066238; -.
DR PaxDb; 9913-ENSBTAP00000045577; -.
DR Ensembl; ENSBTAT00000075568.1; ENSBTAP00000066238.1; ENSBTAG00000034283.3.
DR VEuPathDB; HostDB:ENSBTAG00000034283; -.
DR VGNC; VGNC:25602; ADAD2.
DR GeneTree; ENSGT00940000161900; -.
DR InParanoid; A0A3Q1N6R9; -.
DR OMA; AKNFYFK; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000034283; Expressed in spermatid and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0008251; F:tRNA-specific adenosine deaminase activity; IBA:GO_Central.
DR GO; GO:0006382; P:adenosine to inosine editing; IBA:GO_Central.
DR GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR Gene3D; 3.30.160.20; -; 1.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR014720; dsRBD_dom.
DR PANTHER; PTHR10910:SF106; ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 1.
DR SMART; SM00552; ADEAMc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 84..150
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 230..545
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 58418 MW; 715B7A9BE0D0034D CRC64;
MASVRRKPRL AASLQISPGS SPWKPSASLG QEPAPAPNAD NDEPGGQRMG RSLRVAVPPA
GPAGDFPKIT RHRGLQLKDP PLGQAVASLT QYAANLGVSL IFRESQTADP CSPFSVSVEL
DGVVCPPGTA NSKLEAKQQA ALSALHYIRR QLEGPAPPKT PNQPPLAPLS IENIVTHEQR
CAAVVSAGFD RLVDASSPYR ACKGTVAAVI LEREVPGARG HAKETYQLVA LGTGGGSCTG
WLDFSGRQLH DCHGLVVARR ALLRFLFRQL LLATQGGPTG KEKSVLAPKP GPGPPFALKP
RIFLHLYVSN TPKGAAYDIY LPPSLEGSLL HGPPLRLQAH IQGELKPVCY VAPALRDTHV
GCLSASDKLA RWAVLGLGGA LLAHFLPPLY TTSLVLADTC HDPPTLSRAI HTRPSLDRLV
GPGLPAPYTR TTLHLFAGPS VAPSNLTPNT CQGLSLNWSL GDPDIEVVDV ATGRVKADTA
PGPPSRLCKA AFLRAFRQAA HALGKSHLLA LQTYEAAKAG PYQEARQQLS VLLDQQGLGA
WPSKPLVGKF KN
//
