ID A0A3Q1NA87_BOVIN Unreviewed; 1035 AA.
AC A0A3Q1NA87;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Cysteine rich transmembrane BMP regulator 1 {ECO:0000313|Ensembl:ENSBTAP00000068137.1};
GN Name=CRIM1 {ECO:0000313|Ensembl:ENSBTAP00000068137.1,
GN ECO:0000313|VGNC:VGNC:27710};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000068137.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000068137.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068137.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000068137.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068137.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q1NA87; -.
DR SMR; A0A3Q1NA87; -.
DR STRING; 9913.ENSBTAP00000068137; -.
DR PaxDb; 9913-ENSBTAP00000011877; -.
DR Ensembl; ENSBTAT00000083246.1; ENSBTAP00000068137.1; ENSBTAG00000009020.6.
DR VEuPathDB; HostDB:ENSBTAG00000009020; -.
DR VGNC; VGNC:27710; CRIM1.
DR GeneTree; ENSGT00940000160910; -.
DR InParanoid; A0A3Q1NA87; -.
DR OMA; FNNVEYH; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000009020; Expressed in intramuscular adipose tissue and 104 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1NA87; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 6.20.200.20; -; 5.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR045813; CRIM1_C.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011061; Hirudin/antistatin.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 4.
DR Pfam; PF19442; CRIM1_C; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00093; VWC; 6.
DR SMART; SM00121; IB; 1.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 3.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57262; Leech antihemostatic proteins; 3.
DR PROSITE; PS51252; ANTISTASIN; 4.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1035
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018720527"
FT TRANSMEM 939..959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..112
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 334..391
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 401..457
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 469..498
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 505..532
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 539..564
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 567..592
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 606..663
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 677..735
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 751..809
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 817..874
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
SQ SEQUENCE 1035 AA; 113842 MW; 85C9757AEB8F53C5 CRC64;
MYLVAGGRGL AGCGHLLVSL LGLLLLLARS GTRALVCLPC DESKCEEPKS CPGSIVQGFC
GCCYMCARQR NESCGGAYGL HGACDRGLRC VIRPPLNGDS ITEYEVGVCE DENWDDDQLL
GFEPCNENLV SGCNLINGKC ECDTIRTCNN PFEFPRKDMC LSALKRIEEE KPDCSKARCE
VQFSPRCPED SVLIEGYAPP GECCPLPSRC VCDPAGCLRK VCQPGYLNIL VSKASGKPGE
CCDLYECKPV FSVDCSTVEC PSFQQTVCPL DSYETQVRLT ADGCCTLPTR CECLSGLCGF
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN ETKPACVFNN VEYGDGDMFR MDNCRFCRCQ
GGVSICFTAQ CGELSCERYY MPEGECCPVC EDPVYPLNNP AGCYANGQIH AHGDRWREDD
CTFCQCINGE PHCVATACGQ SCMSPVKVPG ECCPVCEEPT YITIDPPACG ELSNCTLTEK
DCIYGFKLDH NGCRTCQCKN REELCTGLRR GCTLNCPFGF LTDAYGCETC QCRPRPRKCR
PTVCEKHCPF GYLKNKHGCD ICRCKKCPEL RCSKICSLGF QKDSHGCLIC KCREVSASAG
PPVLSGTCLS MDGHHHKNGE SWHDGCRECY CHSGREMCAL ITCPVPACGN PTIHPGRCCP
SCSDDFVVQK PELSTPSICH APGGEYFVEG ETWHIDTCTQ CTCHSGRVLC ETEVCPPLLC
QNPTRTQDSC CPQCPDEPLQ PSSSHNDSVP SYCKNDEGDI FLAAESWKPD VCTSCVCMDS
VISCYSESCP SVSCERPVLR KGQCCPYCIE DTIPKKVVCH FSGKAYADEE RWDIDSCTHC
YCLQGQTLCS TVSCPPLPCI EPINMEGSCC PMCPEMYVPE PTNIPIEKTN HREIDMEVPL
WPTPSENDII HLPRDVGHPQ TDHRENTRLN SEESSVDSIA SVVVPIIIGL SIVIAFLFIN
QKKQWVPLLC WYRTPTKPSS LNNQLVSVDC KKGTRVQVDG SQRMLRIAEP DARFSGFYSM
QKQNHLQADN FYQTV
//
