ID A0A3Q1ND55_BOVIN Unreviewed; 576 AA.
AC A0A3Q1ND55;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=2-hydroxyacyl-CoA lyase 1 {ECO:0000313|Ensembl:ENSBTAP00000069407.1};
GN Name=HACL1 {ECO:0000313|Ensembl:ENSBTAP00000069407.1,
GN ECO:0000313|VGNC:VGNC:29740};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000069407.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000069407.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000069407.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000069407.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000069407.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal;
CC Xref=Rhea:RHEA:55196, ChEBI:CHEBI:57376, ChEBI:CHEBI:74116,
CC ChEBI:CHEBI:138631; Evidence={ECO:0000256|ARBA:ARBA00000194};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55197;
CC Evidence={ECO:0000256|ARBA:ARBA00000194};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR AlphaFoldDB; A0A3Q1ND55; -.
DR Ensembl; ENSBTAT00000066646.1; ENSBTAP00000069407.1; ENSBTAG00000003718.6.
DR VEuPathDB; HostDB:ENSBTAG00000003718; -.
DR VGNC; VGNC:29740; HACL1.
DR GeneTree; ENSGT00940000156802; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000003718; Expressed in liver and 108 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1ND55; baseline.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02004; TPP_BZL_OCoD_HPCL; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 3.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR045025; HACL1-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR43710; 2-HYDROXYACYL-COA LYASE; 1.
DR PANTHER; PTHR43710:SF2; 2-HYDROXYACYL-COA LYASE 1; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q1ND55};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 18..66
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 192..320
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 389..545
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 576 AA; 63196 MW; B7F17101BD76A21F CRC64;
MSESNLAALS DGLEGQVSGA RVIAQALKTQ DVNYMFGIVG IPVTEIALAA QEVGIRYIGM
RNEQAVSMDS EPSGSCLPLT PLILYAYQSQ RPLIVIGGSS ERSQETMGAF QEFPQVEACR
LYSKFSARPS SIEAIPSIIE KAVRSSIYGR PGACYVDIPA DFVSLQVNVS SVKYVECCMP
PPISMAETSA VRMAASVIRN AKQPLVIIGK GAAYAHAEES IRKLVEQCKL PFLPTPMGKG
VIRDNHPNCV AAARSRALQF ADVIVLLGAR LNWILHFGLP PRYQPDVKFI QVDICAEELG
NNVRPAVTLL GDVNAVTKQL LEQFDKTPWQ YPPESEWWKV LREKMKSNEA LSKELASKKS
LPMNYYTVFY HVQEQLPREC FVVSEGANTM DIGRTVLQNY LPRHRLDAGT FGTMGVGLGF
AIAAAIVAKD RNPGQRVICV EGDSAFGFSG MEVETICRYN LPIVLLVVNN NGIYQGFDTD
SWKEMLKFGD ATTVAPPMCL LPHSHYEHVM TAFGGKGYFV QTPEELQKSL RQSLADTTNP
SLINIMIEPQ GTRKAQVKAI AKQKASLNPP PKVSTK
//
