ID A0A3Q1NIL9_BOVIN Unreviewed; 1657 AA.
AC A0A3Q1NIL9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Signal induced proliferation associated 1 like 2 {ECO:0000313|Ensembl:ENSBTAP00000071882.1};
GN Name=SIPA1L2 {ECO:0000313|Ensembl:ENSBTAP00000071882.1,
GN ECO:0000313|VGNC:VGNC:34629};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000071882.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000071882.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000071882.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000071882.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000071882.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSBTAT00000082909.1; ENSBTAP00000071882.1; ENSBTAG00000000942.6.
DR VEuPathDB; HostDB:ENSBTAG00000000942; -.
DR VGNC; VGNC:34629; SIPA1L2.
DR GeneTree; ENSGT00940000157388; -.
DR Proteomes; UP000009136; Chromosome 28.
DR Bgee; ENSBTAG00000000942; Expressed in prostate gland and 104 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1NIL9; baseline.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF7; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 593..810
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 948..1024
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1327..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1593..1641
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 44..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1657 AA; 182814 MW; 013D0644D2D46746 CRC64;
MSDPRQSQEE KHKLGRACSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS LTASSSNESG
GPANGTPAVP KMGVRARVSE WPPKKDCSKE LTCKTLWESR SQTSYESVTS IIHNGQNDGS
EGQQEEPLDL DFVEAKYTIG DIFVHSPQRG LHPIRQRSNS DVTISDIDAE DVLDQNAVNP
NTGAALHREY GSTSSIDRQG LSGENFFAML RGYRLENYDH KAMAPFGFPE FFPCDPAISP
SLHAAAQISR GEFVRISGLD YMDSALLLGR DRDKPFKRRL KSESVETSLF RKLRAVKSEH
ETFKFACELE DGRLERGVRP WNCQRCFAHY DVQSILFNIN EAMATRANVG KRKNITTGAS
AASQTQMPAG PPGSCDSPLG SKEDLNSKEN LDADEGDGKS NDLVLSCPYF RNETGGEGDR
RIALSRANSS SFSSGESCSF ESSLSSHCTN AGVSVLEVPR ENQPIHREKV KRYVIEHIDL
GAYYYRKFFY GKEHQNYFGI DENLGPVAVS VRREKVEDPK EKEGSQFNYR VVFRTSELTT
LRGAILEDAI PSTARHGTAR GLPLKEVLEY VIPELSIQCL RQASSSPKVS EQLLKLDEQG
LSFQHKIGIL YCKAGQSTEE EMYNNETAGP AFEEFLDLLG QRVRLKGFSK YRAQLDNKTD
STGTHSLYTT YKDYELMFHV CTMLPHTPNN RQQLLRKRHI GNDIVTIVFQ EPGALPFTPK
SIRSHFQHVF VIVKVHNPCT ENVCYSVGVS RSKDVPPFGP PIPKGVTFPK SAVFRDFLLA
KVINAENAAH KSEKFRAMAT RTRQEYLKDL AENFVTTATV DTSAKFSFIT LGAKKKEKVK
PRKDAHLFSV GAIMWHVVAR DFGQSADIEC LLGVSNEFIM LIEKDSKNVV FNCSCRDVIG
WTSGLMSIKV FYERGECILL SSVDSCAEDV REIVQRLGIV TRGCETVEMT LRRNGLGQLG
FHVNFEGIVA DVEPFGFAWK AGLRQGSRLV EICKVAVATL THEQMIDLLR TSVTVKVVII
QPHDDGSPRR GCSELCRIPM VEYKLDSEGA PCEYKTPFRR NTTWHRVPTP ALQPLPRVSP
VPGTPDRLQC QPLLPQSQAA IPRSTSFDRK LPDGTRSSPS NQSSSSDPGP GSSGPWRPQV
GYDGCQSPLL LEHQGSGPLE CDGAREREDT VEGSRHAETK WHGPPSKVLS SYKERGLQKD
GGCKDSPNKL SHIGDKSCSS HSSSNTLSSN TSSNSDDKHF GSGDLMDPEL LGLTYIKGAS
TDSGIDTAPC MPAAVLGPVH LAGSRSLVHG RAEQWADSDI PGPDDEQAKM YAVHGYAPGI
STSGAADGSL GDLSEISSHS SGSHHSGSPS AHCSKSSGSL DTSKVYIVSH GSGQQAPGSM
SKAYHRQAAV NKYIIGWKKS EDSPPPEEPE VAECQGLYSE MDLLSSAAQQ QAVVGDAVSE
TQHVLSKEDF LKLMLPDSPS VEEGRRKFSF YGNLSPRRSL YRTLSDESIC SHRRGSSFGS
SRSSILDQAL PNDILFSTTP PYHSTLPPRT QPVPSVGSLR NQRVASFCTL TDMHPEQDLE
GAQELPLCVD PGSGKDFMDP AGERSPSTLT GKVNQLELIL RQLQTDLRKE KQDKAVLQAE
VQHLRQDNLR LQEESQTAAA QLRKFTEWFF NTIDKKP
//
