ID A0A3Q1NIW1_BOVIN Unreviewed; 975 AA.
AC A0A3Q1NIW1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Formin like 1 {ECO:0000313|Ensembl:ENSBTAP00000072010.1};
GN Name=FMNL1 {ECO:0000313|Ensembl:ENSBTAP00000072010.1,
GN ECO:0000313|VGNC:VGNC:29046};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000072010.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000072010.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000072010.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000072010.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000072010.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR AlphaFoldDB; A0A3Q1NIW1; -.
DR Ensembl; ENSBTAT00000084293.1; ENSBTAP00000072010.1; ENSBTAG00000004196.6.
DR VEuPathDB; HostDB:ENSBTAG00000004196; -.
DR VGNC; VGNC:29046; FMNL1.
DR GeneTree; ENSGT00940000156292; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000004196; Expressed in blood and 107 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1NIW1; baseline.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF2; FORMIN-LIKE PROTEIN 1; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 1..415
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 513..904
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 106..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..512
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 108715 MW; CFFC23B99C5FE81A CRC64;
MPRLPSPECW IPRLRLFTCQ YDNEKKWELI CDQVRTGPGP THQSPPVFGS QFKRRVQEST
QVLRELEISL RTNHIGWVQE FLNEENRGLD VLLDYLAFAQ CSVTTDNGAP GSEKSKPLEQ
SVEDLSKGPP SSLPPPPKSR HLTIKLTPAH SKKALRNSRI VSQKDDVHVC IMCLRAIMNY
QSGFSLVMNH PACVNEIALS LNNKNPRTKA LVLELLAAVC LVRGGHDIIL SAFDNFKEVC
GEQHRFEKLM EYFRNEDSNI DFMVACMQFI NIVVHSVENM NFRVFLQYEF THLGLDLYLE
RLRLTESDKL QVQIQAYLDN IFDVGALLED TETKNAVLEH MEELQEQVAL LTERLRDAEN
ESMAKIAELE KQLSQARKEL ETLRVRSRGS GLGGNKGWAG LPRTDHVGAS RLDTSLHPGK
RMGPAPGAAP PPPPPPPPPP PPPLPPLPGL PSQQEAPPLA PPLAPPLPGS PEPPPPPPLP
GDQPPPPPPP PPPPGADGQV PPPPPPPPGG VKAKKPIQTK FRMPLLNWVA LKPNQITGTV
FTELNDEKVL QELDMSDFEE QFKTKSQGPS VDLSALKSKA AQKAPSKATL IEANRAKNLA
ITLRKGNLGA DRICQAIETY DLQTLGLDFL ELLTRFLPTE YERSLITRFE REQRPIEELS
EEDRFMLRFS RIPRLPERMN TLTFLGNFPD TAQMLMPQLN AIIAASMSIK SSDKLRQILE
IVLAFGNYMN SSKRGAAYGF RLQSLDALLE MKSTDRKQTL LHYLVKVIAE KYPQLTGFHS
DLHFLDKAGS VSLDSVLGDV RSLQRGLELT QREFVRQDDC VVLKEFLRVN SPVMDKLLAD
SKTAQEAYES VVEYFGENPK TTSPSMFFSL FSRFIKAYKK AEQEVEQWKK EAAAQEAGTD
TAGKGEPQAP KSPPKVRRQQ MDLISELKRK QQKEPLIYEG DRDGAIEDII TGGGLAGAVL
SWVLAAHSPV GSWGV
//
