ID A0A3Q1NKI3_BOVIN Unreviewed; 497 AA.
AC A0A3Q1NKI3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=KPNA3 {ECO:0000313|Ensembl:ENSBTAP00000072854.1,
GN ECO:0000313|VGNC:VGNC:30702};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000072854.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000072854.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000072854.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000072854.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000072854.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions in nuclear protein import.
CC {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR AlphaFoldDB; A0A3Q1NKI3; -.
DR SMR; A0A3Q1NKI3; -.
DR Ensembl; ENSBTAT00000080687.1; ENSBTAP00000072854.1; ENSBTAG00000004850.6.
DR VEuPathDB; HostDB:ENSBTAG00000004850; -.
DR VGNC; VGNC:30702; KPNA3.
DR GeneTree; ENSGT01050000244891; -.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000004850; Expressed in longissimus thoracis muscle and 109 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1NKI3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0042564; C:NLS-dependent protein nuclear import complex; IEA:Ensembl.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF6; IMPORTIN SUBUNIT ALPHA-4; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..34
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 90..134
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 133..160
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 260..298
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 497 AA; 55020 MW; 255030A7A4CD1128 CRC64;
MRRHRNEVTV ELRKNKRDEH LLKKRNVPQE ESLEDSDVDA DFKAQNVTLE AILQNATSDN
PVVQLSAVQA ARKLLSSDRN PPIDDLIKSG ILPILVKCLE RDDNPSLQFE AAWALTNIAS
GTSAQTQAVV QSNAVPLFLR LLHSPHQNVC EQAVWALGNI IGDGPQCRDY VISLGVVKPL
LSFINPSIPI TFLRNVTWVI VNLCRNKDPP PPMETVQEIL PALCVLIYHT DINILVDTVW
ALSYLTDGGN EQIQMVIDSG VVPFLVPLLS HQEVKVQTAA LRAVGNIVTG TDEQTQVVLN
CDVLSHFPNL LSHPKEKINK EAVWFLSNIT AGNQQQVQAV IDAGLIPMII HQLAKGDFGT
QKEAAWAISN LTISGRKDQV EYLVQQNVIP PFCNLLSVKD SQVVQVVLDG LKNILIMAGD
EASTIAEIIE ECGGLEKIEV LQQHENEDIY KLAFEIIDQY FSGDDIDEDP SLIPEATQGG
TYNFDPTANL QTKEFNF
//
