ID A0A3Q1NM03_BOVIN Unreviewed; 1581 AA.
AC A0A3Q1NM03;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Unc-13 homolog A {ECO:0000313|Ensembl:ENSBTAP00000073541.1};
GN Name=UNC13A {ECO:0000313|Ensembl:ENSBTAP00000073541.1,
GN ECO:0000313|VGNC:VGNC:36664};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000073541.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000073541.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073541.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000073541.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073541.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSBTAT00000080894.1; ENSBTAP00000073541.1; ENSBTAG00000012682.6.
DR VEuPathDB; HostDB:ENSBTAG00000012682; -.
DR VGNC; VGNC:36664; UNC13A.
DR GeneTree; ENSGT00940000161905; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000012682; Expressed in prefrontal cortex and 24 other cell types or tissues.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF1; PROTEIN UNC-13 HOMOLOG A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..97
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 441..491
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 547..671
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 979..1122
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1230..1372
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1405..1531
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 177..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1581 AA; 179065 MW; D6FAC190E6B0AAAA CRC64;
LFLSLSTVKK AKFDGAQEKF NTYVTLKVQN VKSTTIAVRG SQPSWEQDFM FEINRLDLGL
TVEVWNKGLI WDTMVGTVWI PLRTIRQSNE EGPGEWLTLD SQVIMADSEI CGTKDPTFHR
ILLDTRFELP LDIPEEEARY WAKKLEQLNA VLASTACSLS LSLPPFLTLS PHLLSLSDDD
PDSAVDDRDS DYRSETSNSI PPPYYTTSQP NASVHQYSVR PPPLGSRESY SDSMHSYEEF
SEPRALSPTG SSRYASSGEL SQGSSQLSED FDPDEQSLQG SELEDERDRD SYHSCHSSVS
YHKDSPRWDQ DEDELDEELD EELDEDLEDF LEEEEELPED EEEAKANWLR AFNKVRLQLQ
EVSGSSSLAT PGGGLIIIDS MPDIRKRKPI PLVSDLSLVQ SRKAGITSAL ASSTLNNEEL
KNHVYKKTLQ ALIYPISCTT PHNFEVWTAT TPTYCYECEG LLWGIARQGM RCTECGVKCH
EKCQDLLNAD CLQRAAEKSS KHGAEDRTQN IIMVLKDRMK IRERNKPEIF ELIQEIFAVT
KTAHTQQMKA VKQSVLDGTS KWSAKISITV VCAQGLQAKD KTGSSDPYVT VQVGKTKKRT
KTIYGNLNPV WEENFHFECH NSSDRIKVRV WDEDDDIKSR VKQRFKRESD DFLGQTIIEV
RTLSGEMDVW YNLDKRTDKS AVSGAIRLHI SVEIKGEEKV APYHVQYTCL HENLFHFVTD
VQNNGVVKIP DAKGDDAWKV YYDETAQEIV DEFAMRYGVE SIYQAMTHFA CLSSKYMCPG
VPAVMSTLLA NINAYYAHTT ASTNVSASDR FAASNFGKER FVKLLDQLHN SLRIDLSMYR
NNFPASSPER LQDLKSTVDL LTSITFFRMK VQELQSPPRA SQVVKDCVKA CLNSTYEYIF
NNCHELYSRE YQTDPKGEVP PEEQGPSIKN LDFWSKLITL IVSIIEEDKN SYTPCLNQFP
QELNVGKISA EVMWNLFAQD MKYAMEEHDK HRLCKSADYM NLHFKVKWLY NEYVAELPAF
KDRVPEYPAW FEPFVIQWLD ENEEVSRDFL HGALERDKKD GFQQTSEHAL FSCSVVDVFS
QLNQSFEIIK KLECPDPQIV GHYMRRFAKT ISNVLLQYAD IISKDFASYC SKEKEKPCIL
MNNTQQLRVQ LEKMFEAMGG KELDAEASDI LKELQVKLNN VLDELSRVFA TSFQPHIEDC
VKQMGDILSQ VKGTGNVPAS ACSSVAQDAD NVLQPIMDLL DSNLTLFAKI CEKTVLKRVL
KELWKLVMNT MEKTIVLPPL TDQTGTQMIF NAAKELGQLS KLKDHMVREE AKSLTPKQCA
VVELALDTIK QYFHAGGVGL KKTFLEKSPD LQSLRYALSL YTQATDLLIK TFVQTQSAQV
HGGKGTRFTL SEDIYPEKGS GVEDPVGEVS VHVELFTHPG TGEHKVTVKV VAANDLKWQT
SGIFRPFIEV NIIGPQLSDK KRKFATKSKN NSWAPKYNES FHTLSADTGP ECYELQVCVK
DYCFAREDRT VGLAVLQLRE LVQRGSAACW LPLGRRIHMD DTGLTVLRIL SQRSNDEVAK
EFVKLKSDTR SAEEGGAAPA P
//
