ID A0A3Q1NMM9_BOVIN Unreviewed; 3083 AA.
AC A0A3Q1NMM9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dynein axonemal heavy chain 12 {ECO:0000313|Ensembl:ENSBTAP00000073877.1};
GN Name=DNAH12 {ECO:0000313|Ensembl:ENSBTAP00000073877.1,
GN ECO:0000313|VGNC:VGNC:111286};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000073877.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000073877.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073877.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000073877.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073877.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSBTAT00000070151.1; ENSBTAP00000073877.1; ENSBTAG00000020802.6.
DR VEuPathDB; HostDB:ENSBTAG00000020802; -.
DR VGNC; VGNC:111286; DNAH12.
DR GeneTree; ENSGT00940000154280; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000020802; Expressed in spermatid and 100 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1NMM9; baseline and differential.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 2.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 491..630
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 772..911
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1141..1289
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1886..1951
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3083 AA; 351289 MW; 10D6EA5528C6A296 CRC64;
FNICCKMCLE VINSFSFLLD YIPTVSILCN PGMRARHWKQ LSEIVGYDLT PDSGTTLRKI
LKLNLAPYLD KFEVISAGAS KEFSLEKAMH TMMGTWDDIA FHISLYRDTG VCILSSVDEI
QALLDDQIIK TQTMRGSPFI KPFEKEIKAW EDRLIRIQET IDEWLKVQAH WLYLEPIFCS
EDIMQQMPEE GRQFQTVDRH WRDIMKFCAK DPKVLAATSL TGLLEKLQNC NELLEKIMKG
LNAYLEKKRL FFPRFFFLSN DEMLEILSET KDPLRVQPHL KKCFEGIAKL EFLPNLDIKA
MYSSEGERVE LIALISTSAA RGAVEKWLIQ VEDLMLRSIH DVIAAARLAY PESARRDWVR
EWPGQVVLCV SQMFWTSETQ EVISGGTEEL QNQLNDIVEL VRGKLSKQTR ITLGALVTID
VHARDVVMDM IDMDFQWLAQ LRYYWEYDNA RVRIINCNVK YAYEYLGNSP RLVITPLTDR
CYRTLIGAFY LNLGGAPEGP AGTGKTETTK DLAKALAVQC VVFNCSDGLD YLAMGKFFKG
LASSGAWACF DEFNRIELEV LSVVAQQILC IQRAIQQKLE VFTFEGTELK LNPNCFVAIT
MNPGYAGRSE LPDNLKVLFR TVAMMVPNYA LIAEISLYSY GFLNAKPLSV KIVMTYRLCS
EQLSSQFHYD YGMRAVKAVL IAAGNLKLKF PNENEDILLL RSIKDVNEPK FLSHDIPLFN
GITSDLFPGV KLPEADYHEF LECAHEACKV HNLQPVKFFL EKMIQTYEMM IVRHGFMLVG
EPFAGKTKVL HMLADTLTLM NERGCGEEEK VIYRTVNPKS ITMGQLFGQF DPVSHEWTDG
IVANTFREFA LSETPDRKWV VFDGPIDTLW IESMNTVLDD NKKLCLMSGE IIQMSPQMSL
IFETMDLSQA SPATVSRCGM IYLEPSQLGW KPLVSSWLNS LKGPLQEPDH QALLRGLFDW
LIKPTLKLRK KKCKELIPTS DSNVVVSLTR LFEVLLCNAV ENDPTSKHIR VWIMVGLYLL
CFLSYRIKGA CFIFSLIWSI GGSCDTDGRI VFDVYIRIVL MGKDENNPIP DSVGKWECNF
DEKGLVYDYM YELKNRGRWI HWNELIKSTS LGNRRVKIQD IIVPTMDTIR YTFLMDLSIT
YAKPLLFVGP TGTGKSVYVK DKLMNHLEKD LYFPFYVNFS ARTSANQVQN IIMARLDKRR
KGVFGPPMGK KCIIFIDDMN MPALEKYGAQ PPIELLRQFF DCGNWYDLKD TSKITLVDIQ
LIAAMGPPGG GRNPVTPRFI RHFNICTINT FSDETMVRIF SSIVAFYLRT HDFPPEYFLV
GNQIVSGTME IYKQSMENLL PTPTKSHYTF NLRDFSRVIQ GCLLIERDAV EGKHTMIRLF
VHEVLRVFYD RLINDSDRFW LIIISIYHRY VLEHLSRICR ILKQSGGNAL LVGLGGSGRQ
SLTRLATSMA KMQIFQPEIS KSYGMNEWRE DLKGQKTVFL ITDTQIKEEA FLEDIDSVLN
TGEVPNIFAA DEKQEGVRPV AQAGNKHGEL SPLALFAFFV NRCKENLHVV VAFSPIGDAF
RNRLRQFPSL INCCTIDWFQ PWPEDALERV AVKFLETLEL TDVERREIVP ICKHFHTSIM
ELSERFLQEL GRHNYVTATS YLELIASFRQ LLTKRRQAIM EAKQRYVNGL DKLAFAGSQV
GEMKTELVQL QPKLEEAKVE NANMMQVKLE AKRKFVKFDE EIASGKAEEA QTLKNECESD
LAEAIPALEA ALSALDTLKP ADITIVKSMK NPPSGVKLVM AAVCVMKDIK PEKISDPSGT
GGKILDYWGP SKKLLGDMNF LRDLREYDKD NIPVTVMQKI RGEYLTNPEF DPPKVAKASS
AAEGLCKWIM AMEVYDRVAK VVAPKKARLT EAQKSLAETM ELLNQKREEL AEVEHHLENL
ERIFLEKTEE KARLEDQVEL CAKKLERASK LIGGLGGEKS RWSQAADDLQ IVYENLTGDV
LISAGVIAYL GAFTSGFRQT CTEDWSMLCK EKKIPCSEEF SLSKTLGDPV TIRAWNIAGL
PTDTFSVDNG VIVNNSRRWP LMIDPQGQAN KWIKNSEKEN QLSVIKLSDA DYMRTLENCI
QFGTPLLLEN VGEELDPSLE PLLLRQTFKQ GGIDCIRLGE VIIEYSFDFK FYITTKLRNP
HYMPELATKV SLLNFMITPE GLEDQLLGIV VAKERPELEE ERNALILQSA ANKKQLKDIE
KKILETLSSS EGNILEDESA IKILDSAKLM SNEITKKQQI AEKTELKIAE SREGYRPIAK
HSSVLFFSIA DLANIDPMYQ YSLIWFVNLY INSIHDSNKS KILEKRLRYL NDHFTYNLYC
NICRSLFEKD KLLFSFLLCA NLLLAKKEIE YQELMFLLTG GVSLKSAEKN PDPTWLQDKS
WEEICRASEF PIYDSKEPHN AKFPAPMDTR LNELQKIIIL RCLRPDKITP AITNYVTDKL
GKKFVEPPPF DLTKSYLDSN CTIPLIFVLS PGADPMASLL KFANDKAMSG NKFQAISLGQ
GQGPIATKMV KAAIEEGTWV CLQNCHLAVS WMPMLEKICE DFSPEACNSS FRLWLTSYPS
PKFPVTILQN GVKMTNEPPT GLRLNLLQSY LTDPVSDPEF FSGCEGKELA WEKLLFGVCF
FHALVQERKK FGPLGWNIPY GFNESDLRIS IRQLQLFINE YDTIPFEAIS YLTGECNYGG
RVTDDWDRRL LLTMLADFYN PHIIENSHYK FSPSGNYFAP PKGTYNEYIE FIKKLPFTQH
PEIFGLHENV DISKDLQQTK VLFESLLLTQ GGSKQTGSSG STDQILLEIT KDILNKLPSD
FDIESALLKY PVRYEESMNT VLVQEMERFN NLIKTIRNTL RDLEKAIRGV VVMDSALEAL
SGSLLVGKVP EIWAQRSYPS LKPLGSYITD FLARLNFLQD WYNSGKPCVF WLSGFFFTQA
FLTGAMQNYA RKYTIPIDLL GYEFEVIPSD TSKEAPEDGV YIHGLYLDGA RWDRTSGLLA
EQYPKLLFDL MPIIWIKPSK SIKSKIVKSN AYVCPLYKTS ERKGTLSTTG HSTNFVIAML
LKTDQPTQHW IKRGVALLCQ LDD
//
