ID A0A3Q1NNA6_BOVIN Unreviewed; 936 AA.
AC A0A3Q1NNA6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSBTAP00000074213.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSBTAP00000074213.1,
GN ECO:0000313|VGNC:VGNC:55172};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000074213.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000074213.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000074213.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000074213.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000074213.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1NNA6; -.
DR Ensembl; ENSBTAT00000076518.1; ENSBTAP00000074213.1; ENSBTAG00000013110.6.
DR VEuPathDB; HostDB:ENSBTAG00000013110; -.
DR VGNC; VGNC:55172; FARP2.
DR GeneTree; ENSGT00940000158642; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000013110; Expressed in retina and 103 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1NNA6; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0022405; P:hair cycle process; IEA:Ensembl.
DR GO; GO:0016322; P:neuron remodeling; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0071800; P:podosome assembly; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:0033623; P:regulation of integrin activation; IEA:Ensembl.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 46..326
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 527..722
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 751..855
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 394..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 632..659
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 394..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 105056 MW; 1044D3683A06D07E CRC64;
MGELEGTYRV LQTPGARLGT ATPVGVSTLE PGQGPPARAA RPAARTHIRV QLLDDSVEVF
DIEPKCDGQA LLTQVWERLN LIECDYFGLE SQNAQSCWIW LEPMKPIIRQ VRRPKNAVLR
LAVKFFPPDP GQLQEEYTRY LFALQLKRDL LEERLTCTDT TAALLASHLL QAEVGDYDEA
LDREHLRAHE YVPRQERALH RILAFHRELA GQTPAESDFQ VLEIARKLDM YGIRFHSASD
REGAKIKLAV SHTGVLVFQS STRINTFNWS RLRKLSFKRK RFLIKLHPEV HGPYQDTLEF
VLGSRDECKN FWKICVEHHT FFRLLDQPKP KAKAVLFSRG SSFRYSGRTQ KQLADYVKDG
GMKRVPYERR HSRTQMSLRA LKVDLPRQSI SFSEGVRTPV TPSPTTASFC SAPASPPVPP
GSRDFQVGSG SSETGPPAPG AWRPAAERSS MATAQPLRLP ALQPHQGLSV ESPQPSPSTQ
RSPPGLSPQG PAVQGPNPLL GPVLSDAAGA GMDDREEPKR KCVPTDEAYF IAKEILATER
TYLKDLEVIT VWFRSAVVKA DAMPADLMTL LFSNIDPIYE FHRGFLREVE QRLALWEESS
STQATGSHQR IGDILLRNML QLKALTGHFQ RLHEVLTELE AASRRLRRLE ALRRDFELQK
VCYLPLNAFL LKPLQRLRHY RLLLRRLCAP VPGHPDPHGQ DHADLRDALQ AITEVTSMLQ
HSLVQLENLQ KLTELQRDLV GIESLVAPGR ELIREGCLHK LSRKGLQQRM FFLFSDMLLY
TSRDAGGSSH FRIRGLLPLH GMLLIVLDPP VEDQESEWSV PHCFTIYAAQ KTIVVAASTR
LEKAKWLHDL NAAIDAAKTG SALVPPARVL CPLPREPAFW ISAEKVQEQQ WLAEALGGLH
QFLLVLLQNS SGRPPPGQPP AAGLQCEPAQ GHGRHP
//
