ID A0A3Q2C612_CYPVA Unreviewed; 1544 AA.
AC A0A3Q2C612;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Slit guidance ligand 2 {ECO:0000313|Ensembl:ENSCVAP00000000029.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000000029.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000000029.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSCVAT00000015754.1; ENSCVAP00000000029.1; ENSCVAG00000023442.1.
DR GeneTree; ENSGT00940000158402; -.
DR OMA; CQAIRCK; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 6.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45836:SF23; LRRCT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01463; LRRCT; 4.
DR Pfam; PF01462; LRRNT; 4.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00041; CT; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00274; FOLN; 2.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SMART; SM00369; LRR_TYP; 17.
DR SMART; SM00082; LRRCT; 4.
DR SMART; SM00013; LRRNT; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..1544
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018547184"
FT DOMAIN 908..943
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 945..984
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 986..1022
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1024..1062
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1064..1100
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1109..1145
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1148..1342
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1346..1377
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1380..1416
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1422..1458
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1463..1543
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 933..942
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 974..983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1012..1021
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1052..1061
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1090..1099
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1135..1144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1367..1376
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1384..1394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1406..1415
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1426..1436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1448..1457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1544 AA; 170045 MW; 967F63D22EBCC9AC CRC64;
MVGLVRSVGL VRSWETEPRL LLLGTALLLV LLSKADGQPC PPPCSCTGTT VDCHGQGLRS
VPRNIPRNTE RLDLNANNLT KIAKGDFAGL RHLRVLQLME NKITTIERGA FQDLKELERL
RLNRNNLAVF PELLFLGTAK LHRLDLSENQ IQGIPRKAFR GAVEIKNLQL DYNHISCIED
GAFRALRDLE VLTLNNNNIS RLSVASFNHM PKLRTFRLHS NNLQCDCHVA WLSEWLRQRP
RLGLYTQCMA PPHLRGHNVA EVQKKEFVCT GHQSSSSSSC SVLQCPESCT CSNNIVDCRG
KGLTEIPTNL PETITEIRLE QNAIKVIPAG AFSPYKKLRR IDLSNNQISE LASDAFQGLR
SLNSLVLYGN KITEISKGLF EGLFSLQLLL LNANKIACLR VDAFQDLHNL NLLSLYDNKL
QTIAKGTFSS LRAIQTLHLA QNPFICDCHL KWLADYLQDN PIETSGARCT SPRRLANKRI
GQIKSKKFRC SAREQYIIPG NEDYRSKLGG DCFADLACPE KCRCEGTTVD CSNQKLTKIP
DHIPQYTTEL RLNNNEFTVL EATGIFKKLP QLRKINLSNN RISDIEEGTF EGASGVNELI
LTSNRLENIH HRMLKGLSGL RTLMLRSNKI SCVSNSSFVG LSSVRLLSLY DNQITSMSPG
AFDTLHSLST LNLLANPFNC NCHLAWLGDW LRRKRIVTGN PRCQNPYFLK EIPIQDVAVQ
DFACEDGNNE NSCSPVLRCP AECSCLDTVV RCSNKGLTTL PKGVPKETTE LYLDGNHFTQ
VPVELSNYKH LTLIILSYNR LRCIPVRAFD GLMSLRLLSL HGNDISLIPE GAFKDLSSLS
HLALGANPLY CDCHMQWLSD WVKSGYKEPG IARCAGPGDM TDKLLLTTPS KKFTCTGPVD
LSIQAKCDPC LSSPCKNDGT CSSDPVHYYR CTCPYGFKGQ NCEEPIHACI GNPCQNGGTC
HLKEGEGSNF WCVCPEGFEG DTCEINIDDC EDNDCENNST CVDGINNYTC MCSPEYTGEL
CEEKLDFCAP ELNPCQHDSK CILTPQGYKC ECTPGYVGEH CELDYDDCEE NKCQNGGHCI
DAVNGYTCIC PEGYSGLFCQ FTPPMVLPRT SPCDNHDCLN GAQCVVVGTD PRCQCLHGYE
GEHCETLVSV NFVNRESYLQ LPSNLLSPQT NISLQIATDE DSGVLLYKGD DDHIAMELYR
GRLRVSYDTG SYPPSAIYSV ETVNDGSFHS VELVAADQTL SLSIDGGPPK SISSINKQST
LSIDSPLYLG GMPEKASGSG GFSALQLSSG GRNGTSFHGC LRNLYINGKL QNLGAGQDQD
TPGPGNLQNN RQWLGNGVEP GCQPCQRGTC IQGDCHPTGH QGFTCTCHPG WTGALCDQQV
TNPCDGNKCI HGTCLPINSY SYSCRCQPGF SGVLCDAQDL DTANPCSASH CKHGRCRVSG
LGKAYCECNS GYTGEACDRE VACRGERVRD VYQRQQGYAA CQTQEKISRL ECRGSCPGGT
EGQGTCCTPL RSKRRKYTFQ CTDGSSFVQE VEKVVKCGCT KCSS
//
