ID A0A3Q2C706_CYPVA Unreviewed; 659 AA.
AC A0A3Q2C706;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Rho guanine nucleotide exchange factor 25 {ECO:0000313|Ensembl:ENSCVAP00000000389.1};
GN Name=ARHGEF25 {ECO:0000313|Ensembl:ENSCVAP00000000389.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000000389.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000000389.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_015226017.1; XM_015370531.1.
DR AlphaFoldDB; A0A3Q2C706; -.
DR STRING; 28743.ENSCVAP00000000389; -.
DR Ensembl; ENSCVAT00000015155.1; ENSCVAP00000000389.1; ENSCVAG00000001291.1.
DR GeneID; 107082071; -.
DR KEGG; cvg:107082071; -.
DR CTD; 569561; -.
DR GeneTree; ENSGT00940000160422; -.
DR OMA; PLEMHDN; -.
DR OrthoDB; 2906033at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 204..380
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 392..507
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 48..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 73892 MW; 03F72E889FD00F15 CRC64;
MRGGHHQRGC GCQHLFRQLL SNCGCCFVRS RAESYSVADS EGSIAPSVGS LPHQASGSIS
PCSHSSSGAS RHPVSALKKW LTNPVRKLSS DPRGGVGKAE KQPFKADGKQ KPLCHSDTRQ
SSLEVHSNYT ILSSEDTECK SPTAVSPSLS SRQNYLCDLL DDSQSPSLTS GVNTLEVEDS
YIGAEDSPSA VMDSEEEKKL ALEKSLYVLA ELIETERLYV EDLGLIVQGY MSMMANQGVP
EDMRGKDRIV FGNIHQIYDW HKDYFLGELE KCISDPDSLA QLFIRHERRL HMYVVYCQNK
PRSEHIVSEY IETYFEDIRQ QLGHRLQLND LLIKPVQRIM KYQLLLKDFL KYYSKAGRDV
EKLQKAVEVM CFVPKRCNDM MNVGRLQGFE GKITAQGKLL QQDTFSVSEQ EGNIVSRVRE
RRVFLFEQLV IFSEPIEKKK GCPLPGYTFK NSIKVSCLGV EGPSEEDPYC LVLTSRGKDG
SITRFIMHAS SMEIQQAWYN DVVQILDSQR NFLNALQSPI EYQRRKGTTN SLGRSMKSAG
VEPTDSSSPM ERRHQPCLLF YNNSLPSLHS PRLSSTSQVS NASAVTLRVG HPPFSSQQQL
SLCEEVKHDC STFSTLSPCS HHRCMGVNAS LQTIAFSDGA NYPALRPNSL DQLKESEQH
//
