ID A0A3Q2C719_CYPVA Unreviewed; 775 AA.
AC A0A3Q2C719;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000000404.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000000404.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR AlphaFoldDB; A0A3Q2C719; -.
DR Ensembl; ENSCVAT00000015132.1; ENSCVAP00000000404.1; ENSCVAG00000001321.1.
DR GeneTree; ENSGT01050000244905; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF41; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 553..655
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 134..161
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 775 AA; 89815 MW; 6B7AF38B3BAE7C65 CRC64;
MAQWERLRQL SPTYWQQLHE LYDRDGLPME VRHYLSAWIE KQEWQRAARD YGLAMVLYQV
LLEHLDIQHS RFVHDMSFLQ QHHIRRYKQS FQMYQDEPCA LASTILWFLE KEKEILNSLE
LLHVEQEAME TSCQQELERK MAGLRNDVQC LEHEIVCLEE QQDEFDFKYQ THKMEAVTDE
AQKNERMKLF QSLINKLNEC RKSTLADLKK LLDRAEALIN LLVRGELVDW QRRQQKSCIG
APDNVSLDQL EKWFTCVADS LFQVREFLNK LEELVGKMTY ENDPIKAQKP ALQKRTDALL
KDLLKSSFVV ETQPSMPQGK GPLVLRTNVQ FSVKTRLLVK FPELNHSMKV NVSMSRYRRF
NVLGTSTKDL NMAESLSGGM VADFRHLTLK EQKSGGSGKG ISDISLSVTE ELHIIYFNTV
FELKGFSVEL QASSLPVVII SNSSQQQSAW ASILWFNMLS QDSKDVMFFA NVPSAPWPQF
GEMLSWQFLS ATKRGLDDDQ RNMIAYKLFG WQQNYDNCKV TWSKFTKDNF PETFWVWFDG
ILVMVKTYLE NLWREGLIMG FVSKGKEKSL LKKKKKGTFL LRFSESVVGG ITFSWVDIDS
YGEPDIKTVQ PFTKVDLCQI QFHEILRNFQ ILEDENVPEN PLRFLYPDTP KDEAFGKWYS
ENTGDENPYM KYIKTKLMFV SKEKTLDPRS PMSCDMTQGE GLEPVNGPYG EAAGESWLSL
LSNPTKAPFK PIFPYHHNVF FTALVWTGVV LHHTLCLGVA MITHFSHGQF GASSA
//
