ID   A0A3Q2C7Y1_CYPVA        Unreviewed;       504 AA.
AC   A0A3Q2C7Y1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 2 {ECO:0000313|Ensembl:ENSCVAP00000000769.1};
GN   Name=ENTPD2 {ECO:0000313|Ensembl:ENSCVAP00000000769.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000000769.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000000769.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   RefSeq; XP_015260705.1; XM_015405219.1.
DR   AlphaFoldDB; A0A3Q2C7Y1; -.
DR   STRING; 28743.ENSCVAP00000000769; -.
DR   Ensembl; ENSCVAT00000014517.1; ENSCVAP00000000769.1; ENSCVAG00000001705.1.
DR   GeneID; 107105105; -.
DR   KEGG; cvg:107105105; -.
DR   CTD; 954; -.
DR   GeneTree; ENSGT01100000263542; -.
DR   OMA; NEECRYQ; -.
DR   OrthoDB; 180318at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF33; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        468..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        165
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         204..208
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   504 AA;  55830 MW;  99900B9308353FB1 CRC64;
     MAQRSSLPIV PIALLLFGLV GILLLTVPTQ EVRDAPGFMY GIVLDAGSSH TALYIYKWPA
     DKQNGTGVVT QHKECKVEGK GISSYAGQNG AAGKSLEKCL DQAVKDIPKE KHQNTPVYLG
     ATAGMRLLNI SNPEQSSQIL QEVGLKIKSY PFNYSGATIL SGQEEGAYGW VTVNYLLENF
     IKYGFIGRWF STGRPTVGAL DLGGASTQIT FVTQDAAGDK RDMMKLRLYG HEYSLYTHSY
     LCYGQDQLLM RLLAQIVKSQ GYAQVVTHPC YPAGYNKTFK MDDIFNSSCT STKKPDPYDS
     HGTLTVQGSG HYEQCMGNVS ELFSFGSCPF SQCSFDQVYQ PNVTGSFVAF SAFYYVHFFL
     QQIVGHKIST TQELEYATEK LCNITYDELM IMAPKSKSYL QNYCASSVFI KILMLRGYGF
     DEESFARISF QKEAGDTSVG WALGYMLKLS SLVPDESVGV RKTLTLGAWR TLLFLFAGLL
     FGICAFLLLR CRDRRKKGGD QSTI
//