ID A0A3Q2C7Y1_CYPVA Unreviewed; 504 AA.
AC A0A3Q2C7Y1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 2 {ECO:0000313|Ensembl:ENSCVAP00000000769.1};
GN Name=ENTPD2 {ECO:0000313|Ensembl:ENSCVAP00000000769.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000000769.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000000769.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR RefSeq; XP_015260705.1; XM_015405219.1.
DR AlphaFoldDB; A0A3Q2C7Y1; -.
DR STRING; 28743.ENSCVAP00000000769; -.
DR Ensembl; ENSCVAT00000014517.1; ENSCVAP00000000769.1; ENSCVAG00000001705.1.
DR GeneID; 107105105; -.
DR KEGG; cvg:107105105; -.
DR CTD; 954; -.
DR GeneTree; ENSGT01100000263542; -.
DR OMA; NEECRYQ; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF33; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 165
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 204..208
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 504 AA; 55830 MW; 99900B9308353FB1 CRC64;
MAQRSSLPIV PIALLLFGLV GILLLTVPTQ EVRDAPGFMY GIVLDAGSSH TALYIYKWPA
DKQNGTGVVT QHKECKVEGK GISSYAGQNG AAGKSLEKCL DQAVKDIPKE KHQNTPVYLG
ATAGMRLLNI SNPEQSSQIL QEVGLKIKSY PFNYSGATIL SGQEEGAYGW VTVNYLLENF
IKYGFIGRWF STGRPTVGAL DLGGASTQIT FVTQDAAGDK RDMMKLRLYG HEYSLYTHSY
LCYGQDQLLM RLLAQIVKSQ GYAQVVTHPC YPAGYNKTFK MDDIFNSSCT STKKPDPYDS
HGTLTVQGSG HYEQCMGNVS ELFSFGSCPF SQCSFDQVYQ PNVTGSFVAF SAFYYVHFFL
QQIVGHKIST TQELEYATEK LCNITYDELM IMAPKSKSYL QNYCASSVFI KILMLRGYGF
DEESFARISF QKEAGDTSVG WALGYMLKLS SLVPDESVGV RKTLTLGAWR TLLFLFAGLL
FGICAFLLLR CRDRRKKGGD QSTI
//