ID A0A3Q2C8H0_CYPVA Unreviewed; 474 AA.
AC A0A3Q2C8H0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Transcription factor binding to IGHM enhancer 3 {ECO:0000313|Ensembl:ENSCVAP00000000979.1};
GN Name=TFE3 {ECO:0000313|Ensembl:ENSCVAP00000000979.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000000979.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000000979.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR AlphaFoldDB; A0A3Q2C8H0; -.
DR STRING; 28743.ENSCVAP00000000979; -.
DR Ensembl; ENSCVAT00000014168.1; ENSCVAP00000000979.1; ENSCVAG00000001957.1.
DR GeneTree; ENSGT00940000157503; -.
DR OMA; QGVLLME; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11397; bHLHzip_MITF_like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF3; TRANSCRIPTION FACTOR E3; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 272..325
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 127..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 52151 MW; 1325B4DD45391E65 CRC64;
FRMESGIVAD IEVDGLIPTD SDTFYQIKSQ PVNIRYLRLN IEASRVLLRQ GLMRQQALEE
EQKEAQQQQR SIDTSSPISL TVTTSCTPAQ VPVEVLKVQT HLENPTRYHI QQAQRQQVRQ
YLSNTMTANQ QPAVQPSPSP KQDSAIELSN ESSPKQEMEE TVIDDIISLE SSLNEDFLTL
IDSGLQLTST LPTAGNMLDM YGGMATPTIT VSNSCPADLH AVKREQTGKS HLNRLCSAGS
RGTSPVFDLS SSSSPSSSAV DVETKALLKE RQKKDNHNLI ERRRRFNIND RIKELGALIP
KSSDPETRWN KGTILKASVD YILKLQKEQQ RAREMEERRE RKPLPAAAHP VLLNIFSFVQ
ELELQARLNG LSSSSSSAST PLTSSSSSLD PNTHLSPLLP NPSLSFMDLE ESHATPTVFS
PDLLPGVGLT ELSSLGGFLM EEDGGAAVMS DPLLSCGASK TSSRRSSFSM DEDL
//
