ID A0A3Q2C8I3_CYPVA Unreviewed; 1285 AA.
AC A0A3Q2C8I3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000000987.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000000987.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00009903}.
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DR STRING; 28743.ENSCVAP00000000987; -.
DR Ensembl; ENSCVAT00000014177.1; ENSCVAP00000000987.1; ENSCVAG00000001937.1.
DR GeneTree; ENSGT01030000234517; -.
DR OMA; IGPACDW; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:UniProtKB-UniRule.
DR CDD; cd22250; ROCK_SBD; 1.
DR CDD; cd05596; STKc_ROCK; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.5.730; Single helix bin; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR015008; ROCK_Rho-bd_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR PANTHER; PTHR22988:SF28; RHO-ASSOCIATED PROTEIN KINASE 2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08912; Rho_Binding; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF103652; G protein-binding domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS51859; RHO_BD; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01206}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 44..306
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 307..377
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT DOMAIN 888..956
FT /note="RhoBD"
FT /evidence="ECO:0000259|PROSITE:PS51859"
FT DOMAIN 1136..1191
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 1113..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 17..47
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 380..935
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 962..989
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1232..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 73
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1285 AA; 149221 MW; 1DB525ABA5ABFDAF CRC64;
SMNALAHDLN YPVLRKNKNI EAFLKRYEKL VNELRELQVK LDDFEKVKLI GRGAYGEVQL
VRHKASKKVY AMKQLSKFEM IKRSESAFFW EERHIMAFSN SPWIVQLCCA FQDDRHLYMV
MEFMPGGDLV TLTINYDIPE KWARFYTAEV VLALDAIHSM GFIHRDVKPD NMLLDQQGHL
KLADFGTCMR MDSTGMVHCE TAVGTPDYIS PEVLQSQGSD GIYGRECDWW SVGVFLYELL
VGETPFYAES LIGTYGKIMN HHNSLVFPDD AEMSQDAKDL ICAFLTDRND RLGRTGVDEI
KRHPFFKNEQ WNFDNIRDTV APVVPELHSD IDTSNFDDIA VDKGAAETFP TPRAFAGNQL
PFIGFTYFKD DQHFFLSFPS EQLLEKVNQL EEQLDHEMQE LRLEASLRQL ERERALLQQQ
SAENLRKVEM EADRKRILEN QINCLKDQLE DMKKKNRDSH IFNENNVQLQ KQLEEANSAL
QAEQKATALL KKSQSEAQKQ AQNLEVSLKE MEKKCSSLEA NKAEQEKQIW ELQAELEEEK
RERNLSTEAL ADLQVTISVL EDEVKEAKSS LSKVKDEKKE LQTKLNNLEK EKNKQEIDLT
FKLKSLQQSL EQEEAEHKAT KAKLSDKKET YQSIEEAKSE ALKEMESTLE EERSLKQQVE
ENLLQLKKDH SMLEWDHKQA QQKLDELQAQ KEKLSEEVMD LTLRLEQEIQ KRSKSQSELK
AHKQQVSVLT SSEKQLKQEF NQLLDMKQSL EKQNQELRRE KQEADGQLKE LMDQLEDEQN
FNTLYRKQIH ELKDENDEKN KMYQEAQQQL AEYQEERASM AAQLESSLKK ADSERLARSV
AEEQYSDLEK EKIMKELEIK DMMARHKQEL NEKEATITSL EESNRTLTVD VGNLASEKEE
LNNQLKELEQ ELQKAKETEK KIESQKLSLE KQIQTEKTLK IQAVNKLSEV MAKRKDQERG
GIRIVNSEVH KTKQENRKLQ QDLKAERQKI NSILFKHQKE LEDVQALLVD ESHHCQELQM
ILDSRESDIE HLRCQLTSLS VHSLDTTSIS SNNDLEIISP CIIEHLKILL HGFPFFLLKL
FHVRPITQTD CYRADVKEIP RIFQILYANE GESKREQEEA EESSPSERSP FVSHKGHEFV
GTIYHLPSSC DACSRPLWNV FKPPAALECR CCHAKFHRDH LDKKEEVIPP CKVNYDVSTA
KDLLLLTGSQ TEQQRWVRHL LKRIPRKTST LSPPPAARNI SDDSLPRSSP QVSPHSSPRT
SPRLSHRRAI KVQSTRHQQT SENSR
//