ID A0A3Q2C958_CYPVA Unreviewed; 487 AA.
AC A0A3Q2C958;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Bone morphogenetic protein 10 {ECO:0000313|Ensembl:ENSCVAP00000001263.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000001263.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000001263.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_015251782.1; XM_015396296.1.
DR AlphaFoldDB; A0A3Q2C958; -.
DR STRING; 28743.ENSCVAP00000001263; -.
DR Ensembl; ENSCVAT00000013693.1; ENSCVAP00000001263.1; ENSCVAG00000002228.1.
DR GeneID; 107098557; -.
DR KEGG; cvg:107098557; -.
DR CTD; 27302; -.
DR GeneTree; ENSGT00940000156279; -.
DR OMA; SAQNKHD; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0060840; P:artery development; IEA:Ensembl.
DR CDD; cd13767; TGF_beta_BMP9_like; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF39; BONE MORPHOGENETIC PROTEIN 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..487
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018535482"
FT DOMAIN 375..487
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 264..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 54837 MW; A64CB5E4CBF81942 CRC64;
MASIWVSQLG TICTSKTFLL FSFLLLQKPL FGNSSPISNA HQRYRPAPGL GDGHGGVVDP
MLLEQDDSTK MQNLLESLKE QFLRTFNLSV MGPSSLQPGS AREDPPEYMM ELYNRFANDH
TAMPTANIIR SFKNEDSNPS DMGVGGVRRH PLLFNVSIPH HERITAAELR LYTLVQTDRH
LYAGVDRKVT IYELTSHDWF NMTAEKLMRG DEFAEIGKRT DVLELASRQV FGTDNGWEAF
DLTAAVQRWS KSDGATTHRL EVHISSIANE ENAESMKGTS KDEGPAEDDM RIENSPEEKH
KPLLIVFSDD QSSDHRDDKR ELNEMIDHET SSAVLQNDYG TESGGLWGED RNEAEPDEED
LIQMRSNLIY DTTSRIRRNA KGNHCKKQSL YVEFKDIGWD SWILAPSGYD AFECAGICSY
PLTKHVTPTK HAIIQTLVNI NSPQKAARAC CVPTKLEPIS LLYLDEKGVV TYKYNYEGMV
VAECGCR
//
