ID A0A3Q2CA61_CYPVA Unreviewed; 518 AA.
AC A0A3Q2CA61;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Target of myb1 like 2 membrane trafficking protein {ECO:0000313|Ensembl:ENSCVAP00000001627.1};
GN Name=TOM1L2 {ECO:0000313|Ensembl:ENSCVAP00000001627.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000001627.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000001627.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TOM1 family. {ECO:0000256|ARBA:ARBA00007708,
CC ECO:0000256|PIRNR:PIRNR036948}.
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DR AlphaFoldDB; A0A3Q2CA61; -.
DR Ensembl; ENSCVAT00000013098.1; ENSCVAP00000001627.1; ENSCVAG00000002639.1.
DR GeneTree; ENSGT00940000156940; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd14238; GAT_TM1L2; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR014645; TOM1.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR13856:SF31; TOM1-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR13856; VHS DOMAIN CONTAINING PROTEIN FAMILY; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036948; TOM1; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR036948};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036948}.
FT DOMAIN 20..152
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 214..302
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT REGION 179..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 56416 MW; 69F1D29BED8736D7 CRC64;
MEFLLGNPYS TPVGQCVERA TDGGLQSEDW TLNMEICDII NETDEGPKDA MRALKKRLSG
NKNFREVMLA LTVLETCVKN CGHRFHVHVA NRDFIDGVLV KIISPKANPP TIVQDKVLSL
IQSWADAFRS SPDLTGVVHI YEELKRKGVE FPMADLDALS PIHTPQRGTP EVDPAMLKYL
APNNSTGGPP KPSQSTPTTT QASNIPSPVT VTPEQIARLR SELDIVRGNI KVMSEMLTEL
VPGQEDASDL ELLQELNRTC RAMQQRVVEL IGRVSNEEVT EELLHVNDDL NNIFLRYERY
ERYRLGRAAQ NNGMLAETTE DNLIDLGPGS PAVVTPRITS SPPSSSAQRD AASATHNPTA
SLSTALANLD VGPDTVSGTL TSLSGPNKDD FDMFAQTRSS SLAEQRKNVK YEEPHALGGL
ASALDVRQQN TSGLRVKGDD NPADQELPID SWLITQGMKG DAAEEGVTSE EFDKFLEERA
KAADTLPSPP GANPAQPARP TTGSSKKAER TEDALFAL
//
