ID   A0A3Q2CAC4_CYPVA        Unreviewed;       693 AA.
AC   A0A3Q2CAC4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=FMR1 autosomal homolog 1 {ECO:0000313|Ensembl:ENSCVAP00000001682.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000001682.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000001682.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule
CC       {ECO:0000256|ARBA:ARBA00004331}.
CC   -!- SIMILARITY: Belongs to the FMR1 family.
CC       {ECO:0000256|ARBA:ARBA00006633}.
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DR   RefSeq; XP_015247522.1; XM_015392036.1.
DR   AlphaFoldDB; A0A3Q2CAC4; -.
DR   Ensembl; ENSCVAT00000013004.1; ENSCVAP00000001682.1; ENSCVAG00000000711.1.
DR   GeneID; 107095766; -.
DR   CTD; 8087; -.
DR   GeneTree; ENSGT00950000183189; -.
DR   OMA; WPARITK; -.
DR   OrthoDB; 2995592at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006417; P:regulation of translation; IEA:InterPro.
DR   Gene3D; 2.30.30.140; -; 2.
DR   Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR   InterPro; IPR008395; Agenet-like_dom.
DR   InterPro; IPR040148; FMR1.
DR   InterPro; IPR022034; FMR1-like_C_core.
DR   InterPro; IPR040472; FMRP_KH0.
DR   InterPro; IPR032172; FXR1_C1.
DR   InterPro; IPR032177; FXR_C3.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR041560; Tudor_FRM1.
DR   PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR   PANTHER; PTHR10603:SF6; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN 1; 1.
DR   Pfam; PF05641; Agenet; 1.
DR   Pfam; PF12235; FXMRP1_C_core; 1.
DR   Pfam; PF16096; FXR_C1; 1.
DR   Pfam; PF16097; FXR_C3; 1.
DR   Pfam; PF00013; KH_1; 2.
DR   Pfam; PF17904; KH_9; 1.
DR   Pfam; PF18336; Tudor_FRX1; 1.
DR   SMART; SM00322; KH; 2.
DR   SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR   PROSITE; PS51641; AGENET_LIKE; 2.
DR   PROSITE; PS50084; KH_TYPE_1; 2.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT   DOMAIN          4..50
FT                   /note="Agenet-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51641"
FT   DOMAIN          63..115
FT                   /note="Agenet-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51641"
FT   REGION          379..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..398
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..444
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..486
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..539
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..560
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        564..578
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..634
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        640..693
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   693 AA;  77268 MW;  6A8301A69342A49B CRC64;
     MEELVVEVRG SNGAYYKGFV KDIHDDSLTI AFENNWQPER QVPFSDVRLP PPADVKKEIG
     EGEEVEILSR ANEQEPCGWW LAKVRMMKGD FYVIEYAACD ATYNEIVTFE RLRPVNPNKA
     VTKNSFHKCT VPVPQDLQEA CQSENAHKDF KKAVGACRIS YCPETSELLI VSTNESTVKR
     VSLLSDMHLR SLRTKLLLMS RNQEATKHLE TSRQLVSSFQ QEFIVRPDLM GLAIGSHGSN
     IQQARKLPGV TAIELDEETG TFRIYGETEE AVKKARNLLE FVEDSVQVPR NLVGKVIGKN
     GKVIQEIVDK SGVVRVRIEG DNDNKQARQE TQGMVPFTFV GTKESIGNVQ VLLEYHISYL
     NEVEQLRLER MQIDEQLRQI TQGHRPVDRE RGDRAERGGG YNADNSGNTS SASLRGSRSY
     NSRGRGRRGQ NHNSGYGANS EHSNASETDS ERKDELSDWS LAGEDLDGER DRGPRPLRDG
     RRRPGPGGGR GGRGGRGRGG RGGYGYSSGS RDHENNHGYG TLETNTETDQ TADTDASESN
     LPANRRRRSR RRRTDEDATL IDGMSESDNA SVSENGIDLT EAKPQRRNRS RRRRMRLPEE
     RQPVTVADYI SRAESQSRQM NTKDPKKNKE VVEAIAEHSP QSAPPTTNGS NNEVSDGPGN
     GADQSQKSST EKPPKVSSYE RDSNPQPVVN GLS
//