ID A0A3Q2CAM9_CYPVA Unreviewed; 369 AA.
AC A0A3Q2CAM9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Protein NDRG2 {ECO:0000256|ARBA:ARBA00015427, ECO:0000256|RuleBase:RU367129};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000001787.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000001787.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC Down-regulates CTNNB1-mediated transcriptional activation of target
CC genes. May be involved in neuron differentiation.
CC {ECO:0000256|RuleBase:RU367129}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU367129}.
CC -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000256|ARBA:ARBA00005598,
CC ECO:0000256|RuleBase:RU367129}.
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DR RefSeq; XP_015259258.1; XM_015403772.1.
DR AlphaFoldDB; A0A3Q2CAM9; -.
DR STRING; 28743.ENSCVAP00000001787; -.
DR Ensembl; ENSCVAT00000012820.1; ENSCVAP00000001787.1; ENSCVAG00000002802.1.
DR GeneID; 107103913; -.
DR KEGG; cvg:107103913; -.
DR CTD; 57447; -.
DR GeneTree; ENSGT00950000182872; -.
DR OMA; KTCFQPL; -.
DR OrthoDB; 5352016at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-UniRule.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR PANTHER; PTHR11034:SF17; PROTEIN NDRG2; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367129};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367129};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|RuleBase:RU367129};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW ECO:0000256|RuleBase:RU367129};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU367129}.
FT REGION 331..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 369 AA; 40578 MW; F83DBFDFC61BF31B CRC64;
MTSEMQEIAI TEEKPLLTGQ GDAAKDAAEL AARILLDQGQ EHSVETPHGV LRVTLHGTRT
TRRPAILTFH DVGLDSKSCF SPLFKFEEMQ EIVKNFTLIH IDAPGQEEGA SAYPPGYQYP
TMETIAEMIP AVLQFFNFRT VIGVGVGAGA YILSKFTLAN PDSVEGLVLI NIDTNAKGWM
DWAAHKLSSV TSSLTEQILC HLFSQEELSS NTDLVTSHRE RISKAPNLAN IELFWKTYNS
RRDLNLDRNY TFKCPVMLVV GDQAPYEEAA VECNSKLDPT STSFLKMADA GGLPQLTQPA
KLTEAFKYFI QGMGYMASSC MTRLSRSRTT SLSSSYSMDG SRSRSRTLSQ GSQGGQMPPS
PSQTMEVSC
//
