ID A0A3Q2CBM8_CYPVA Unreviewed; 1579 AA.
AC A0A3Q2CBM8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Uncharacterized LOC107087196 {ECO:0000313|Ensembl:ENSCVAP00000002301.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000002301.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000002301.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Ntn-hydrolase family.
CC {ECO:0000256|ARBA:ARBA00010872}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00464}.
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DR RefSeq; XP_015234115.1; XM_015378629.1.
DR RefSeq; XP_015234116.1; XM_015378630.1.
DR STRING; 28743.ENSCVAP00000002301; -.
DR Ensembl; ENSCVAT00000011957.1; ENSCVAP00000002301.1; ENSCVAG00000003376.1.
DR GeneID; 107087196; -.
DR KEGG; cvg:107087196; -.
DR GeneTree; ENSGT00740000115744; -.
DR OMA; PRMKGMK; -.
DR OrthoDB; 2343191at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR CDD; cd04701; Asparaginase_2; 1.
DR Gene3D; 3.60.20.30; (Glycosyl)asparaginase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR004364; Aa-tRNA-synt_II.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR000246; Peptidase_T2.
DR PANTHER; PTHR10188; L-ASPARAGINASE; 1.
DR PANTHER; PTHR10188:SF42; SI:CH211-256M1.8; 1.
DR Pfam; PF01112; Asparaginase_2; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF00152; tRNA-synt_2; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF54197; HIT-like; 2.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1091..1195
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT DOMAIN 1260..1570
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
FT COILED 31..58
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 300
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
FT ACT_SITE 801
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR600246-1"
SQ SEQUENCE 1579 AA; 174499 MW; 51BAAB95F19B9BAC CRC64;
MTLVDYPLPQ LDTTLQEVSR VLQLTLSPDL YPEFKSTLEK QRNALEEAQK KIEALAAGQE
NWVTRQFKKG LLSCADPLPT STALPVVLLP SKAKGCSQLA RAAALLWAAA KLYSEPLLLE
GDVPLEDTQQ SEVFAASRIP GKSQDEIKVY PDSLHAIITC AGGAFPVDIL WRPSTGGQVS
ARSFLDIYKQ LAQVMDLPRA GKQNDPSVVC SLSTLERKSW AALREEILKQ EGDGHKSLEL
MESAILILCL EDSNAPTEMA DILNAVRLGG GGDSPRLRYY DKVLNLVVFK DSTAGMVFEH
SAVDGMVASL VTERVYHLSE TVDINLVNND LGKMVKPDTL NTVHSACPKG LTFPFEGITK
LQQNPVLTAD NLVLTFDLPS YPDVFSTLRG QRGLYDAWVN FSLQLSLWQT LGESASKHML
VTPTHMRHYK HGRCDPTYSL TVHSRKLVNT LASHISPDNT IRYSNDLLQL FHLAFLEHKN
LIRNTKTGQG VGPHLAALRR SLPPDNPLRK FLNPFGCPSV YLTGSDMMEG VECGVGNVYA
QDQLAVTYLG KKDKVRLVLN GKGSFAVALK RLQENLKLNL KLMMLLAVRY AITSQMGALD
SLFKQQQTEQ MLQCPENLDK GKGAPDSGSG KSSDYILVIH GGAGEDIKLN TKVTEMIEFA
LETALALGAQ ILEQGGSSLD AVQRSVEALE DCFLFNAGRG SVFNKDGKNE MEATIVDGSR
MTSGSVACLK TVKNPIKAAR CVMEKSSHSL IVGEGAEEFL QGMGDKTKPV GQDYFYTDTR
YKELMAKLSD GNTSKNNHPQ TVGAVALDRL NTLAAATSTG GLVGKLKGRV GDTAIVGAGI
YADDKVAITC SGDGDVFLRT SVAEKIASLY HNKGYGLRQA CREVISQNLK DVSAGIIAVD
KKGDAVIETN AGVMFVASMN GGISRVEVLR PIKSFTNVIW ETDELVAYLN PNPWTPGSVI
ITRKTLSGPT SIFQLPTPDF VAMLQAAKTV SNLLCERLGV QRCALIFYPN PSKPAQIKLL
PLYGLQPKWQ PHLAEEEEFY SHDTGFCNSK SGPRWNDEAL NQVQAKIRSA LPTPNAPFCF
DYFGDPSTDN LFSRIIQGEQ QQWRVWEDSE HVAFLTPYPN RPGLTVVVPR RPLSSDIFRL
NNLQYNALIF ATYKVAKLLQ EGMKAPSVAL IFEGFEIDHA HVKLVPLLPP PDGTKAEELQ
PEFFQTYPGF VSSLDGPMAD AESLKDIHLK ITRCTPPHSW KDPQVHSTLA INSQWYRNLF
QIQNTLFHST VEYFHNSCQF SYALTPLTTD TISSPMGLGS DSEPVSVSLL GQDVYLADSM
QFVLEYFLRF QENLAGAYYI SPSFRGEDPD ATHLNQFYHV ECELLGDMNK AISIAEGYLV
HVTKCMLKHH SDMIQNSAGT LTHVTEFLSK MEGENTLPRI PLDRAISMMH SADCLEWVQD
GQPHFGRKLT RKGERVLIEK FGGAVWLTEM DHLGVPFYQA YVEGTGRCKA KAADLLLGLG
ETIGLGERHS TPEMVREALK HHAVAEESYK WYITMRKVMP LLTSGWGMGT ERYLCWLLQH
DDVRDLHIIP RMKGIKYMP
//
