ID A0A3Q2CCF1_CYPVA Unreviewed; 1703 AA.
AC A0A3Q2CCF1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rap guanine nucleotide exchange factor 6-like {ECO:0000313|Ensembl:ENSCVAP00000002568.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000002568.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000002568.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR Ensembl; ENSCVAT00000011501.1; ENSCVAP00000002568.1; ENSCVAG00000003862.1.
DR GeneTree; ENSGT00940000158124; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR PANTHER; PTHR45161:SF4; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 284..384
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 416..529
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 534..603
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 758..844
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 869..1096
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 123..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1580..1626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1641..1683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..245
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1703 AA; 189129 MW; 0E8B0B68231AD2E3 CRC64;
MKMTGAMETT FKVALKKPPS LRTAEDLHII YCHLYHMDVL SHLREHQLRS MCTSARYERY
EANHILFYPD SLATCWYVLL SGSVFVKEHM YLARCCFGKQ LGGRRGCECI TLEPSEMIVV
DNGTEGDDSF LQRDGSQRRS RRRFRRVNPK GERELITDGQ EPASYSNTLP ADLNKMHLTD
HAHQQVMHMA PSQSGCSITS DSGSSSLSDI YQATESDLGD VDLSGLPEAP VDSEEEEEED
EDLERASDTL LGRDLVRECL EKDPVDRNDD DIEQLLEFMH QLPAFANMTM SVRRELCSVM
VFEVVEQSGT IILHNKQELD HWYVILNGAV EISHPEARTE TLCMGNSFGI SPSLDKQYMN
GEVRTKGDDC QFVCIAQEDY WRILNHVEKN THKVEEEGEI VMVKEHRELD RSGTRKGHIV
IKGTPERLIM HLVEEPSVVD PTYIEDFLLT YRTFLSSPMD VGRKLLEWFQ VDSLRDTVTR
IVLLWVNNHF NDFEGDAAMT RFLEEFEKHL ETSKMKGHLR LLNIACAAKA KWRQITLQKA
SRESQLHFSV QGGSERGFGV FVESVEEGSK AAEAGLKRGD QIMEVNGQNF ENIALSKAVD
ILKHNTHLSL TVKTNIFVFK ELLSRIVHEK KNGGPHIPKI QEKKGNRFSI ADLPGDIEFP
TDSKSTRKMK ANTVSGGRNR IRKMLEKTRF SILPPKPFRG LFGDGGLVQS QDDSIVGTKQ
CRHSVAIMPI PGNLSSSSPD LLQPANSVLD FSNPADIPDQ VIRVFKADQQ SCYIIISKDT
TAKDVVAHTV NEFGLLAAPE TYSLCEVSVS PEGVIKQRRL PDQLSKLADR IQLNGRYYLK
NNMETETLCS DEDAQDLLRE SQISLLQLST MEVAAQLSMR DFELFRNIES TEYVEDLFKL
DSSAGCTNLK QFEEVMNQET FWVASEILKE PNTLKRMKTI KHFIKIALHC RECKNFNSMF
AIISGLNLAP VARLRSSWEK LPSKYEKLFE DLQDVFDPSR NMAKYRNVLS SQSMQPPIIP
LFPVVKKDLT FLHEGNDSSV DGLVNFEKLR MIAKEIRHVV RMTSANMDPA LMFRQRKKRW
KSLGSLSQGS TNSNILDVQG GAHKKRVRRS SLLNAKKLYE DAQMARKVKQ YLSNLTVETD
EDKHQIMSLQ CEPSYNTLGK NLSERRSNKS DMSPVSLRAT LPSGKTQNRV SQVLQVQVPL
NPLRKKSTAK DTGASNSNSP QVVKKPAVNS SDEWNTKRPS DDTVSTVSSL HSSPTVSPQG
SPRKVGGVAK SQNSSQMNLS GSSSSLTSDT STKTGTISLR SYGIGCPLLP MGKSDNMSDS
SHSEISSRSS ICSVDSAQAS GPDDRSNRTC SNTTTSATLA PNATAATAAV VAEGTAALNA
HLTADYSQPS TSSSVLARGF AGRPFSSSLS TEELTPDHTS LDLAVDSGRG SWTSCSSNSH
ESFQILPTSS CRPWDHGIHG YPLSLPHAHL SGFKHTALGR PIAEAEAAGP SWANDIPANR
HTRDSSSDLS RQGHESWTSS GSLSDNYEGN YGTIKRRNTS EHPSSPVTEE GGQSTDASYK
TVTSSTEKGL IVYCVTSPTK DERYRAPPPT PPGYQGLALG DLGLTDGVVS GPGSSAPRPP
HLKPPDYSVA LQRSKLLQSP GAASGLAEVR RLHHQESRTS SSTQGKSRPP SIGHRSQDLA
DSEDGRSDLL CSYIFRKYIR TQH
//
