ID   A0A3Q2CCF8_CYPVA        Unreviewed;       677 AA.
AC   A0A3Q2CCF8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Dynein cytoplasmic 1 heavy chain 1 {ECO:0008006|Google:ProtNLM};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000002614.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000002614.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   AlphaFoldDB; A0A3Q2CCF8; -.
DR   STRING; 28743.ENSCVAP00000002614; -.
DR   Ensembl; ENSCVAT00000011429.1; ENSCVAP00000002614.1; ENSCVAG00000003743.1.
DR   GeneTree; ENSGT00940000156103; -.
DR   OMA; HEACHEL; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF12777; MT; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          1..69
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          140..471
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   DOMAIN          500..666
FT                   /note="Dynein heavy chain ATP-binding dynein motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12781"
FT   COILED          144..192
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          341..438
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   677 AA;  77765 MW;  8809C638FA7949D1 CRC64;
     MNGLSVYQIK VHRKYTGEDF DEDLRTVLRR SGCKNEKIAF IMDESNVLDS GFLERMNTLL
     VPDYMPIVYD KLPQPPSHRE AIVNGCVFVH QTLHQANNRL AKRGGHTMAI TPRHYLDFIN
     QYANLFNEKR SELEEQQMHL NVGLRKIKET VDQVEELRRD LRIKSQELEA KNAAANDKLK
     KMVKDQQEAE KKKVMSQEIQ EAVYKQQEVI KDKQLSVKQD LDQVEPAVIE AQNAVKSIKK
     QHLVEVRSMA NPPAAVKLAL ESICLLLGES TTDWKQIRSI IMRENFIPTI VNFSAEEISD
     SIREKMKKNY LSNPSYNYEG VNRASLACGP MVKWAIAQLN YADMLKRVEP LRNELQKLED
     DATDNKTKAE EVEQMIRDLE ASIARYKEEY AVLISEAQAI KADLAAVEAK VNRSTALLKS
     LSAERDRWEK TSETFKNQMS TIAGDCLLSA AFITYAGYFE QQMRQNLFTT WSHHLQQANI
     QFRTDIARTE YLSNADERLR WQANSLPADD LCTENAIMLK RFNRYPLIID PSGQATEFIM
     NEYKDRKITR TSFLDDAFRK NLESALRFGN PLLVQDVESY DPILNPVLNR EVRRTGGRVL
     ITLGDQDIDL SPSFVIFLST RDPTVEFPPD LCSRVTFVNF TVTRSSLQSQ CLNEVLKAER
     PDVDEKLVVF KVLFGLL
//