ID A0A3Q2CEG0_CYPVA Unreviewed; 364 AA.
AC A0A3Q2CEG0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=PDZ and LIM domain protein 4 {ECO:0000256|ARBA:ARBA00039369};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000003401.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000003401.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004159}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004159}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004159}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
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DR RefSeq; XP_015260546.1; XM_015405060.1.
DR AlphaFoldDB; A0A3Q2CEG0; -.
DR STRING; 28743.ENSCVAP00000003401; -.
DR Ensembl; ENSCVAT00000010107.1; ENSCVAP00000003401.1; ENSCVAG00000004581.1.
DR GeneID; 107104942; -.
DR KEGG; cvg:107104942; -.
DR CTD; 8572; -.
DR GeneTree; ENSGT00940000159536; -.
DR OMA; QYNNPTR; -.
DR OrthoDB; 370973at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR InterPro; IPR031847; PDLI1-4/Zasp-like_mid.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24214:SF6; PDZ AND LIM DOMAIN PROTEIN 4; 1.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR Pfam; PF15936; DUF4749; 1.
DR Pfam; PF00412; LIM; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00132; LIM; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 8..84
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 287..346
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 85..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 39396 MW; 4B1BB309B3F20D39 CRC64;
MSNTVTLKGP SPWGFRLVGG RDFSTPLTIS RVTPGSKAAQ GDLCPGDTIL AINGDSTEHM
THMEAQNKIK TCTQQLTLSI IRSGSGDRVW SPTVSEDGKI SPYAEPDAQN FRPITSVSGS
YGRKPSYTSE PQSPLAPQPT HLNNGNSRPN NGHSYGYGNG TGQPQYNNPA GLYAHNGSNG
DRSLPGKMGG LSLSATHSPE PPPQSPVSRN GFDPQSDVYK MLQDYEEPVS APKQSGSFKY
LQEILDAEDG GLSPTERMRS LRSPVRSPIP KLGSPIPPPT TGLQKLPQCT RCCNGIVGTI
VKARDKLYHP DCFICDDCSI NLKQRGYFFI EDNLYCETHA KARVQPPEGY DVVAVYPNSK
VELV
//
