ID A0A3Q2CER7_CYPVA Unreviewed; 692 AA.
AC A0A3Q2CER7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Frizzled class receptor 3 {ECO:0000313|Ensembl:ENSCVAP00000003437.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000003437.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000003437.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR RefSeq; XP_015247376.1; XM_015391890.1.
DR AlphaFoldDB; A0A3Q2CER7; -.
DR Ensembl; ENSCVAT00000010048.1; ENSCVAP00000003437.1; ENSCVAG00000004608.1.
DR GeneID; 107095678; -.
DR KEGG; cvg:107095678; -.
DR CTD; 565921; -.
DR GeneTree; ENSGT00940000156491; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF144; FRIZZLED-3 ISOFORM X1; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..692
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018548920"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..145
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 207..514
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 552..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 37..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 45..91
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 112..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 692 AA; 78019 MW; 962D0BE2F62CA144 CRC64;
MWGPVMDLLW VLSVSMLAAC VAIPMDAAAG SHSLFTCEPI TLRMCQGLPY NSTFMPNSMN
HYDQQTAALA MEPFHPMVNL HCSPDLRMFL CAVYAPVCTE YGRMTSPCRR LCLQAKSDCY
KLMDMFGVSW PEEMDCNRFP DCDEPYPRPV DLLPSSETTE SPVSIQRDYG FWCPRELKID
PELGYSFMGV RDCSPPCPNM YFSRQELTFA RYFIGVVSIV CLSATLFTFL TFLIDVSRFR
YPERPIIFYA VCYMMVSLVF FLGFLLEDRV SCNAASPGRF RASTVTQGSH NKACTLLFMV
LYFFTMAGSV WWVILTITWF LAAVPKWGSE AIEKKALLFH ACAWGVPGIL TVTLLAMNKI
EGDSVSGVCF VGLYNLTALR WFLLAPLGLD VLVGVVLLLA GIAALNRVRM EIPLEKENQE
KLVKFMIRIG VFSVLYLVPL LTVIACYLYE SSYRTVWETT WVQEKCRDYH IPCPYKVERS
SRPDLALFLI KYLMMLIVGI PSVFWVGSKK TCFEWASFFH GKRRKDGMVN DSRQVLQEPD
FAQLLYRDPN TPIVRKSRGT STQGTSTHAS STHLAMLDEP PSASTSRAES VRSARSKMSS
YHGSLHRSRD GRYTASSFRA LEERLAYGSM PRLSDQSSTT RLDGLIRHDS TLRLESQSRH
SSIRDLSAVT QAVLGVPGNG IHRMMDEDGA AA
//
