ID A0A3Q2CER8_CYPVA Unreviewed; 395 AA.
AC A0A3Q2CER8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Transcription factor EC {ECO:0000256|ARBA:ARBA00019430};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000003529.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000003529.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR AlphaFoldDB; A0A3Q2CER8; -.
DR STRING; 28743.ENSCVAP00000003529; -.
DR Ensembl; ENSCVAT00000009900.1; ENSCVAP00000003529.1; ENSCVAG00000004727.1.
DR GeneTree; ENSGT00940000159404; -.
DR OMA; STEWHLS; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18926; bHLHzip_MITF; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF1; TRANSCRIPTION FACTOR EC; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 155..208
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 263..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 208..242
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 263..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 44350 MW; 63CEC55EBE33ABF8 CRC64;
MPHLSDCSYY KMRDATRASK VQSHLENSKF HLQSQNQPVK QYLTLGSKLA SSAGPNHTLP
HPHAPGQPLA TVPIMRNGHM ATVSDGSNPN SPVTLLTMAN HDSEFPMDEV IDDLISLESG
FNEGGLDCME PNIIMQSNVS INHLHDTRVM AKERQKKDNH NLIERRRRYN INYRIKELGT
LIPKSNDPDM RWNKGTILKA SVEYIRWLQK EQQHSRELES RQKKLEQANR RLLLRIQELE
IQARAHGLPN MATSLGTVEL SSHLLKQQQQ QQQSPPQAQQ QQQPPQPPLY QEDPNSDYLQ
RLAVVTGVPS ITTASGPQDH IQRTDACTTF SDPLSHFTDF FTATLKEENQ LDEILMDDPL
SPFGTDPLLS AGSPGAASKD SSRRSSFSSA EGDDL
//
