ID A0A3Q2CFG1_CYPVA Unreviewed; 872 AA.
AC A0A3Q2CFG1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSCVAP00000003798.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000003798.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000003798.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2CFG1; -.
DR Ensembl; ENSCVAT00000009434.1; ENSCVAP00000003798.1; ENSCVAG00000005072.1.
DR GeneTree; ENSGT00940000158869; -.
DR OMA; SRIHACY; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 4.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 10..61
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 257..349
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 364..453
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 450..584
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 710..808
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 116..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 98353 MW; 156D98E0505C64C8 CRC64;
MASLDGSTAV ETFLAAIHLE RYLHTFRQAG LLLARDFSHL DHDALVSLGV TATGHRKRIL
RLQSGGPGNS PNTDCRLMNP DRAAMKPVPK PRTVFNRRRT APVQFKRRLL SSIPGRPGSL
EGIRLSGSSG SPRGGSMEMV SNEIYWGTSP SSAAISGGRS YSCQQAGPPT PPRNLDRNQN
KNVEGNLDRN RCHKFSWTKR LSQAFHSGDS QGYSTVGEAP PSLRWSSLPP HTFPPEADDD
LTISPYASYT SLTERAPPII SGWLDKLSPQ GNYVFQKRFV KFDGKNLMYF GSEKDVYPKG
VIPLAAIQMA RPAKDNKFEI VTSHRIFVFR TDNEVLRRRW VATLQEHVRD HQVFGRRRFG
PGSHCQKHGV LELKGTKSKV YAAINTDQIW LYKSEQCFRN GIGITVIEAR GATIRDGKHR
SFDLITPYKT FSFTAESDRE KRDWMEALQE AIAETLSDYE VAEKIWSNRS NRMCADCKAL
NPDWASINLC VVICKNCAGQ HRGLGTMVSK VQSLKLDTSV WSNEIVQLFI MLGNDRANDF
WAARLSVSEE LDCDATPEQR REFISQKYRE GRFRLAHPAF NSQEELLKFN SGSGRLADPS
VYDEIMQPIL HSGFLYKASS LSKGTLSRKT REGGIDFQKF WCSVDQSLVL YESEHSADPC
LQINVKDIVL VFSYMLFLFG LETADALHSW TKAIGQAATP LSCHCLLTRE FERVGLLRYR
AMLDPQQWKE AYFVLQKSNL FICPRNDGAA EDIINLNRLQ ELSITSENEN HEKKEILVLV
EKGRTLHLQG VGRTDFPLWY ADIQRAAGGK GNALREQQMS RSDIPIIVDS CIAFITQYGE
ELPENYAPSK QLRVRDQRTF EPIVLVHCRS GP
//