ID A0A3Q2CG41_CYPVA Unreviewed; 263 AA.
AC A0A3Q2CG41;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Lens fiber major intrinsic protein-like {ECO:0000313|Ensembl:ENSCVAP00000003977.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000003977.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000003977.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
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DR RefSeq; XP_015246630.1; XM_015391144.1.
DR AlphaFoldDB; A0A3Q2CG41; -.
DR STRING; 28743.ENSCVAP00000003977; -.
DR Ensembl; ENSCVAT00000009128.1; ENSCVAP00000003977.1; ENSCVAG00000005237.1.
DR GeneID; 107095157; -.
DR KEGG; cvg:107095157; -.
DR CTD; 445140; -.
DR GeneTree; ENSGT00940000156260; -.
DR OMA; IGQNTHE; -.
DR OrthoDB; 3236018at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR GO; GO:0015250; F:water channel activity; IEA:Ensembl.
DR GO; GO:0070309; P:lens fiber cell morphogenesis; IEA:Ensembl.
DR GO; GO:0036438; P:maintenance of lens transparency; IEA:Ensembl.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR034294; Aquaporin_transptr.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR NCBIfam; TIGR00861; MIP; 1.
DR PANTHER; PTHR19139; AQUAPORIN TRANSPORTER; 1.
DR PANTHER; PTHR19139:SF286; AQUAPORIN-0A; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR02014; AQUAPORIN2.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
DR PROSITE; PS00221; MIP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000477};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000477}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 239..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 263 AA; 28659 MW; F91F9114FD5F9606 CRC64;
MWEFRSMSFW RAVFAEFYGT MFFVFFGLGA ALRWTTGPHN VLHVAFAFGL AAATFIQSIG
HISGGHINPA VTFAYLIGSQ MSLFRAFFYI VAQCLGALAG AAVLYGVTPN NMRGNLALNT
LQPGISLGMA TTIEIFLTLQ LVICVFAVTD ERRNGRLGSA ALAIGFSVLI GHLLGMYYTG
AGMNPARSFA PAVLVRNFIN HWVYWVGPMI GGAIGALLYD FLLFPRMRGL SERLATLKGT
RPPEAEAQQE TRGESIELKT QAL
//
