ID A0A3Q2CGM9_CYPVA Unreviewed; 764 AA.
AC A0A3Q2CGM9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dishevelled segment polarity protein 2 {ECO:0000313|Ensembl:ENSCVAP00000004264.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000004264.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000004264.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DSH family. {ECO:0000256|ARBA:ARBA00008735}.
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DR RefSeq; XP_015235010.1; XM_015379524.1.
DR AlphaFoldDB; A0A3Q2CGM9; -.
DR STRING; 28743.ENSCVAP00000004264; -.
DR Ensembl; ENSCVAT00000008631.1; ENSCVAP00000004264.1; ENSCVAG00000005544.1.
DR GeneID; 107087778; -.
DR KEGG; cvg:107087778; -.
DR CTD; 1856; -.
DR GeneTree; ENSGT00950000182903; -.
DR OMA; CENYLVN; -.
DR OrthoDB; 2910598at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd04438; DEP_dishevelled; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR024580; Dishevelled_C-dom.
DR InterPro; IPR008339; Dishevelled_fam.
DR InterPro; IPR003351; Dishevelled_protein_dom.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR015506; Dsh/Dvl-rel.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10878; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR PANTHER; PTHR10878:SF8; SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF02377; Dishevelled; 1.
DR Pfam; PF00778; DIX; 1.
DR Pfam; PF12316; Dsh_C; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR01760; DISHEVELLED.
DR SMART; SM00021; DAX; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 1..82
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT DOMAIN 257..329
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 425..499
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 95..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..115
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..734
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 83311 MW; E6040AD3DE25FF9F CRC64;
MAETKIIYHI DEEETPYLVK IPIAAENITL LDFKQVLNKP NYKFFFKSMD QDFGVVKEEI
SDDGAKLPCF NGRVVSWLVS SETPAAEPPV AVVPPVETAS QPSPPPPPLP PPPAERTGGI
GDSRPPSFHP NATGSVETLD EQTETESVVS FRRERPRHRE NVEQHGPRMN GQSRLERHLA
GYESSSTVMS SELETTSFCD SDDDDTMSRF SSATEQSTAS RLLKRHRRRR KQRPPRLERA
SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM KGGAVAADGR
IEPGDMLLQV NDINFENMSN DDAVRVLREI VHKPGPIILT VAKCWDPSPQ GYFTLPRNEP
IRPIDPAAWV SHSVAMTGAF PPYPGSSSLS TITSSSSVTE TERFDDFSLS LHSDMASVAK
AMASPESGLE VRDRMWLKIT IPNAFLGSDV VEWLFHHIEG FQDRREARKY ASNLLKAGFI
RHTVNKITFS EQCYYVFGDL SDCENYMANL SLNDNDGSSG ASDQDTLAPL PLPGASPWPM
MHTFPYQPYA AHPYSSQPPP YHELSSYSYA PGSTGSQHSE GSRSSGSTRS EGERRRSNKG
PGSTAGGGEK SPSGEGGGGG ESRSGSGSES EYSTRGSLRR GHGSSAQSEH SHASSQRSHH
HRMPQPPHMS PYPPGILPYN PMMLMMVPQH PHPAMAAHAL QHPQQLSAAP MHQALPPPPS
STPGGPPGAP PTRDLGSVPP ELTASRQSFH LAMGNPSEFF VDVM
//
