ID   A0A3Q2CHI6_CYPVA        Unreviewed;       585 AA.
AC   A0A3Q2CHI6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Lactase like {ECO:0000313|Ensembl:ENSCVAP00000004614.1};
GN   Name=LCTL {ECO:0000313|Ensembl:ENSCVAP00000004614.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000004614.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000004614.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family.
CC       {ECO:0000256|RuleBase:RU003690}.
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DR   AlphaFoldDB; A0A3Q2CHI6; -.
DR   STRING; 28743.ENSCVAP00000004614; -.
DR   Ensembl; ENSCVAT00000008055.1; ENSCVAP00000004614.1; ENSCVAG00000005953.1.
DR   GeneTree; ENSGT00940000157369; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR018120; Glyco_hydro_1_AS.
DR   InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF335; LACTASE-LIKE PROTEIN; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 1.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 1.
DR   PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|RuleBase:RU004468};
KW   Hydrolase {ECO:0000256|RuleBase:RU004468};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..585
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018717278"
FT   TRANSMEM        560..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        414
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ   SEQUENCE   585 AA;  67685 MW;  743558515975683A CRC64;
     MQLRCALSVC HVLMLVLCLS TAEDFDWTKN NYGSFYYGTF PTGFSWGAGG SAYQTEGAWD
     KDGKGLSIWD VFSHKKGKIQ LNDTGDSSCE SYYKIKDDVS LMKELRLNHY RFSISWPRII
     PTGIKSDHVN EKGIQYYDEL IDHLLENNIT PIVTLYHWDL PQVLQEKYSG WQNISMINHF
     NDYANLCFEK FGDRVKHWIT FNNPWSVAVE GYETGEHAPG LKLRGTGAYR AAHHIIKAHA
     KVWHTYDTQW RAKQKGLVGV SLAGDWGEPV DISNQKDIEA AERYVQFYLG WFATPMFHGD
     YPQVMKDFVG RKSAQQGLGT SRLPSFSPQE KSYIKGTCDF LGIGHFTTRY ITNRNDPPGR
     SSSSYFTDRD LAELVDPRWP DPGSEWLYSV PWGFRRLLNF VKTQYGNPMI YVTENGVSEK
     MMCTELCDEW RIQYYKEYIN EMLKAIRDGV NVKGYTAWSL LDKFEWDEGF SERFGLYYVD
     FRNKNKPRYP KASVQFYKRI ISSNGFPNQR EVENWRRKAV EMCSSSNQLL AAEEQRSTAA
     NILRLIHDPL TSHMEMVTEI VVPTVCTLSI LISAVLLMFL LRRRN
//