ID A0A3Q2CIR2_CYPVA Unreviewed; 366 AA.
AC A0A3Q2CIR2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Ras association domain family member 1 {ECO:0000313|Ensembl:ENSCVAP00000005022.1};
GN Name=RASSF1 {ECO:0000313|Ensembl:ENSCVAP00000005022.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000005022.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000005022.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_015237580.1; XM_015382094.1.
DR AlphaFoldDB; A0A3Q2CIR2; -.
DR STRING; 28743.ENSCVAP00000005022; -.
DR Ensembl; ENSCVAT00000007375.1; ENSCVAP00000005022.1; ENSCVAG00000006359.1.
DR GeneID; 107089354; -.
DR KEGG; cvg:107089354; -.
DR GeneTree; ENSGT00940000155664; -.
DR OrthoDB; 4260488at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20885; C1_RASSF1; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033614; RASSF1-6.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22738:SF12; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR22738; RASSF; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF16517; Nore1-SARAH; 1.
DR Pfam; PF00788; RA; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50951; SARAH; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 75..125
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 224..314
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 316..363
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
SQ SEQUENCE 366 AA; 41524 MW; 37D2B245A2DB29F2 CRC64;
MMSWGEFIEL RDLNSSSGQM ELTGLRSPCS PPRLERTNAL RISPGKVPDL LSRVGIIRVL
SSSQDPEFVE EKGEGHNFQP CSHAQPTWCD LCGDFIWGLY KQSLRCVNCR FTCHYRCRAL
IQLDCSWERG SAADLTTVVE HTIETDTNVD EQVEHGKPEW TTAEILQKVK EYNSQINSNL
FMNMNKDGSY TGFVKVQFKL ARPVSVPAPK KGGPDAGGRR ASGVKRRTSF YLPKDASKHL
HISSRTSARE VIEALLKKFT VVDNPGKFAL FERSERHDQV YLRKLSDGER PLRLRLNAGP
NEKVLSFVLK ENETGEVNWH AFSMPELKNF LLILQREEEE HVKQIVKRYT LARTKMLEAL
SGSTPG
//
