ID   A0A3Q2CJ33_CYPVA        Unreviewed;      1287 AA.
AC   A0A3Q2CJ33;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Par-3 family cell polarity regulator {ECO:0000313|Ensembl:ENSCVAP00000005157.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000005157.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000005157.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system
CC       {ECO:0000256|ARBA:ARBA00004308}.
CC   -!- SIMILARITY: Belongs to the PAR3 family.
CC       {ECO:0000256|ARBA:ARBA00005358}.
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DR   STRING; 28743.ENSCVAP00000005157; -.
DR   Ensembl; ENSCVAT00000007149.1; ENSCVAP00000005157.1; ENSCVAG00000006540.1.
DR   GeneTree; ENSGT00950000183214; -.
DR   OMA; ADDKDRX; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   Gene3D; 2.30.42.10; -; 3.
DR   InterPro; IPR021922; Par3/HAL_N.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR16484:SF10; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR   PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR   Pfam; PF12053; Par3_HAL_N_term; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   PROSITE; PS50106; PDZ; 3.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT   DOMAIN          275..351
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          467..541
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          593..668
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          81..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          873..1002
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1094..1206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1221..1287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        925..1002
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1113..1131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1143..1168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1182..1200
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1287 AA;  143530 MW;  4DEF81020F9DD12F CRC64;
     MKVTVCFGKT RVVVPCGDGN LKVHALIQQA VMRYKKAIAK DANYWLQVHR LEHGDGGILD
     LDDVLCDVAD DKDRLIAIYE EQEPHHGGDG TSASSTGTQS PDLFAADLGA GSGTSSAFQP
     YQNASEIEVT PSALRTNMPL HVRRSSDPAL ITINGPFSTL ESRVQAEETP SRKNPTRWST
     TAGFLKARHY SGTSSLERKV DTYRSLPRDA GTWSNQREFQ RDTARSSLSA NHPMVDRWLE
     KQEQETRENE NGRIEPVGRA DSCMEHTPVS SLEDIVKVVE VSNDGGPLGI HVVPFSGRDR
     RTLGLLVKRL ERGGKAEHQG LFQENDCIIR INNGDLRNIR FEQAQNMFRQ AMRSPVIMFH
     VVPSSLRAHY EQLSHAERNP SFHSGRFSPD SLSGVDHSSQ RITRHGSQTH PHPATHTHPD
     PNNGYPHLTH PAVSAAKPPT GHTHSPQRAL NSTPTTGYMK KVGRRLNIQL KKGPEGLGFS
     ITSRDVPIGG SAPIYVKNIL PRGAAIQDGR LKAGDRLLEV NGVDLNGRTQ EEVVSLLRNT
     PMGGAVGLLV LRQEDAFLPR EVVSRELSLP LNVPPLDELV LTPDGTREFL TFEIPLSDSG
     SAGLGVSVKG NRSKENHADL GIFVKSIING GAACKDGRLI VNDQLIAVNG ESLLGKTNQD
     AMETLRKSMS TEGNKRGMIQ LIVARRVAKR NEETSGSQLV PQQTANTTLD DHERRISHSL
     YGGLEGLDDN LMPRQGMIPR TIGTIQSFFF LILTWCFLKN HSPMSPDEND PDVAFQREGF
     GRQSMSEKRT KQFGDAAQLE IIKTRKSKSM DLGSSTKDVG PSLGLKKSSS LESLQTAVAE
     VTLNGDLPFH RPRPRIIRGR GCNESFRAAI DKSYDRPAAL EDDDEGMETL EEDTEESSRS
     GRDSVSTVAD QTPLSPGPEK PLVNGTNRSK EEKKKDKDKT GKEKKKQDGG KEKEKGKPKK
     GMLKGLGEMF RFGKYRKDER PAEKMDRKGS SKWRPEETQV SDEETMKMRM EQERIQAKTR
     ELRERQARER DYAEILDVGR TLDRSSEEDH TSLTHNGPLT LIHLTPSFFF FLSPLSNRLT
     PSNHDRIQRL RQEFQQAQNV PEDPDDRRRT YSFEQSWVSP GRHSVSVEVQ MQRQRQEERD
     SFAQAQRQYS SLPRQPRKNP STVSQDSWDK AYPPGDVFQT AKDNPRYSSY QGSRNGYPGS
     SGGGGVNARV LLEAQELLRQ EQRRREQEAK GKRMQESSGN SGYEGYIPRL KEPGSPKGPY
     RHDVPPSPSQ LARLNRLGSE KGRLFYS
//