ID A0A3Q2CJ54_CYPVA Unreviewed; 2319 AA.
AC A0A3Q2CJ54;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000005253.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000005253.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR STRING; 28743.ENSCVAP00000005253; -.
DR Ensembl; ENSCVAT00000007000.1; ENSCVAP00000005253.1; ENSCVAG00000006776.1.
DR GeneTree; ENSGT00390000010427; -.
DR OMA; KQNENRM; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 1751..1931
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 126..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1958..2027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2169..2218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1710..1737
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 126..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1958..1987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1996..2017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2195..2212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2319 AA; 261143 MW; 1D88AEE2C98A3FB0 CRC64;
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTAKSL LFNSKIAEEV NRLLGCRDES
LASQLAHGLN QVSTEHIELK DNLGSDEPEG DAPLLLQTML ARNPGIFREK NVMQQPMVQP
FKITQNSMHS PAQSANFQPA AISPNPSSRF VGPQTGSSSR YSPVPSPYTP QSPAPGYIQQ
FPHQQPPSYN QLQQIQEGSR PQLILQSPPP YASSPREGGH DQKQHLHQRK KAPTVKEEKD
MYDIVSSPNK DSTKLTLKLS RVKSNESDPP AGGLQPPSSP YDEAELDALA EIERIEREAA
SEKCSKEVQD KDKPLKKRKQ DSFPLEPGAG GPGAPTGAPG SGSTGGANAG KLTPQEATAA
GNGASRPPLM VSIDLQQAGR ADGQLDPCLA APIPALEAQR WPEEPASGQA AVEGSDTHRH
HDKSSDRQPG RSSSRQDGSK AASSSTGAKI PDSFPAQLLG GHTGALKNFQ IPKINRDREN
SESTESQMWG QPKVKLERLG LVKDFEKRPK PVVVLKKLSV DQIQRIIRHS KSKNRFSGKS
GKSGMDPEVL KELPPELLEE IESTMPMYER VKMNKRKRST VNEKPKYAEV SSDEDYDRHK
RDKDRSWDIE ERERRGSGEH RKSGHREGRR GSGSRYRDSS EEDSPPPSMS EIARKMKMKE
KQKKRKAYEP KLTQEELMDS STFKRFLASI DNILENLEDV DFTTMDDDEI PQELLLGKHQ
LNELGSESAK IKAMGITSKI PSDKLVKLLN ILEKNIQDGS KLSTLLNHDH DAENEERLWR
DLIMERVTKS ADACLTALNI MTSTHMPKAV YIEDVIERVL QYTKFHLQNT LYPQYDPVYR
VDPHGGGLLS SKAKRAKCST HKQRVIVMLY NKVCDIVSNI SELLEIQLLT DTTILQVSSM
GITPFFVENV SELQLCAIKL VTAVFSRYEK HRQLILEEIF TSLARLPTSK RSLRNFRLNS
SDQDGEPMYI QMVTALVLCL IQCVVHLPND KDVFEEYDKV DQDVLITNSY ETAMRTAQNF
LSVFLKKCGS KQGEEDYRPL FENFVQDLLS TVNKPEWPAL SIFDLNITIL LVHQFSNKQT
EMALRVASLD YLGTVAARLR KDAVTSKMDQ RSIDRILQEG TDETQQLQKA LLDYLEENAE
TDPSLVFARK FYIAQWFRDA TTEAEKSMRN QNPKDEDSSD GPQHAKEMET TGEIMQRAEK
RKKFLRNIIK TIPAHFTTLK MNSDTVDYED SCLIVRYLAS MRPFAQSFDI YLTQILRVLG
ESAIAVRTKA MKCLSEVVAV DPSILARSDM QRGVHGRLMD NSTSVREAAV ELLGKFVLSR
PQLTEQYYDM LIERILDTGI SVRKRVIKIL RDICLEQPTF SKITEMCVKM IRRVNDEEGI
KKLVNETFQK LWFTPTPAHD KDTMTRKILN ITDVVAACRD TGYDWFEQLL QNLLKSEEDA
SYKPAKKACV QLVDNLVEHI LKYEESLAEN KGVNSTRLVA CITTLYLFSK IRAQLMVKHA
MTMQPYLTTK CNTANDFMVI CNVAKILELV VPLMEHPSET FLATIEEDLM KLIIKYGMTV
VQHCVSCLGA VVNKVTHNYK FVWSCFNKFY GALNKFKIQH QEDPNSTTLV ANKPFLLRSL
FTVGALGRHF DFDQEEFKGP NKVIIKEKVL ELLLYFTKHD DEVVKTKAII GLGFLVIMHP
SQMFVPEVKS LYNGILADSA SSINLKIQVL KNLQTYLQEE DSRMQEADRE WKKLSKQEDL
KEMGDISSGM SSSIMQLYLK QVLEAFFHTE SSVRHFALNV IALTLNQGLI HPVQCVPYLI
AMGTDPEPSM RNKADQQLVE IDKKYTGFIH MKAVAGMKMS YSLQQAINLS RKSIVRGFRQ
DETHSALCSH LYTMIRGNRQ HRRAFLISLL NLFDDSAKTE VNMLLFIADN LACFPYQSQE
EPLFIMHHID ITLSVSGSNL LQTFKELLLK EPRRKEKKVK VWKNTSDGED EEKMNCDSSR
SDEEENCNSD GNENEDNNDD VVHRPKKTRK PVGNEDGSDS ESDLEDLDVE DVDKVMRLLP
DNPSGLLDFA NAVQGILLLL VLKQHLKNLY GFSDGKIQKY SPTESAKVYD KAVNRKNNVT
FSPRQTLDFI FNNMGNATLT EDVKRRIVKQ YLDFKVLMEH LDPDEEDEEG EASASANIRN
KAINALLGGS GLLSGPSPRN QAGPETDDDD SDSDDRTPGS SRRSRRAGDS SDPGRMSETV
EAMDVIALCC PKYKDRPQIA RVTQKTANGY TIHWMAGSYS GPWAEAKKRD GRKLVPWVDT
IKESDIIYKK IALTSNHKLS NKVVQTLRSL YAAREGGAS
//
