ID   A0A3Q2CJG9_CYPVA        Unreviewed;       727 AA.
AC   A0A3Q2CJG9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN   Name=GUCY1A2 {ECO:0000313|Ensembl:ENSCVAP00000005388.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000005388.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000005388.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q2CJG9; -.
DR   Ensembl; ENSCVAT00000006768.1; ENSCVAP00000005388.1; ENSCVAG00000006919.1.
DR   GeneTree; ENSGT00940000157765; -.
DR   OMA; SLMLHYF; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR   Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR038158; H-NOX_domain_sf.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR042463; HNOB_dom_associated_sf.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR45655:SF7; GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2; 1.
DR   PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          512..639
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          63..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          453..484
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   727 AA;  81068 MW;  3F7979291E2B63FB CRC64;
     MSSSSRKISS ESFSSSVGSD CGLESPGGDG GDGALEPADE SRGCPFSSFP SAHRAVLWNG
     RSPAERPACP AREEQQQGPC GPHKRATRRR RVNLDSLGES LKRLTSPTTQ TVQEALHRTL
     QFYRKQEIRY EHLTSYLGDV GVFASRFFFS TGVPFCELRE HFGEEFFGLC FEENERVLRA
     VGGNLQDFFN GFDAILEHIR TSTGRRASSE SPSFQCKDPR KVLFLHCFNP APVVGLVMPG
     LIRAVARRIF HSEVEVEEVP PLTPLLPNED AEQTDFPTVC LSFLIQETCT SPTNRPPLHL
     STNPSDLRIS LATFCRAFPF HLVLGHRMEL LQLGEGLRKQ ARIEPHRILS FRDCFEIVSP
     KMEPSFQGIL LRLASPFTIR TRPDPMQAGT KEKVMELKGQ MIHVPESCSL MFLGSPRVDK
     LEELMGRGLH LSDIPIHDAT RDVILVGEQA KAQDGLKKRM DKLKATLERT HQALEEEKRR
     TVDLLYSIFP GDVAQKLWQG QPVPARKFND VTMLFSDIVG FTAVCAHCTP MQVISMLNEL
     YTRFDYQCGI LDVYKIETIG DAYCVAGGLH KKVDSHAKPI AQMALKMMEL SEEVLTPDGK
     PIKLRIGIHT GSVLAGVVGV KMPRYCLFGN NVTLASKFES GSHPRCINVS PTTYQLLKDD
     RSFSFIPRSR LELPDNFPKE IPGTCYFLEA GTSHSHASLT SSRSAPPASM RKVSYSIGTM
     FLRETSL
//