ID   A0A3Q2CJH2_CYPVA        Unreviewed;       858 AA.
AC   A0A3Q2CJH2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx {ECO:0000256|ARBA:ARBA00015210};
DE            EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
DE   AltName: Full=Interferon-inducible Mx protein {ECO:0000256|ARBA:ARBA00031810};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000005359.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000005359.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR   RefSeq; XP_015255908.1; XM_015400422.1.
DR   AlphaFoldDB; A0A3Q2CJH2; -.
DR   STRING; 28743.ENSCVAP00000005359; -.
DR   Ensembl; ENSCVAT00000006817.1; ENSCVAP00000005359.1; ENSCVAG00000006733.1.
DR   GeneID; 107101485; -.
DR   KEGG; cvg:107101485; -.
DR   CTD; 406525; -.
DR   GeneTree; ENSGT00940000155764; -.
DR   OrthoDB; 1052588at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   CDD; cd08771; DLP_1; 1.
DR   CDD; cd01256; PH_dynamin; 1.
DR   Gene3D; 1.20.120.1240; Dynamin, middle domain; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR11566; DYNAMIN; 1.
DR   PANTHER; PTHR11566:SF23; DYNAMIN-2; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003932};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU003932};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          28..294
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   DOMAIN          516..621
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          650..741
FT                   /note="GED"
FT                   /evidence="ECO:0000259|PROSITE:PS51388"
FT   REGION          739..858
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        765..806
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        821..847
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   858 AA;  96594 MW;  49F504A5BEED37B8 CRC64;
     MGNRGMEDLI PLINKLQDAF SSIGQSCNLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG
     SGIVTRRPLI LQLVNSKAEY AEFLHCKGRK FVDFEEVRME IEAETDRLTG SNKGISPIPI
     NLRVYSPNVL NLTLIDLPGM TKVAVGDQPV DIEHQIRDML LQFITKESCL ILAVTPANTD
     LANSDALKIA KEVDPQGLRT IGVITKLDLM DEGTDARDIL ENKLLPLRRG YIGVVNRSQK
     DIDGKKDIRA ALAAERKFFL SHPAYRHIAE RMGTPHLQKT LNQQLTNHIR DTLPGLRSKL
     QSQMLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKCIEGSGDQ VDTSNLSGGA
     KINRIFHERF PFELVKMEFD EKELRKEISY AIKNIHGVRT GLFTPDMAFE AIVKKQIIKL
     KEPCLKCIDL VIQELINTVR QCTNKLDSYP RLREETERIV TTHIRERDNK TKEKVLLLID
     IELSYINTNH EDFIGFANAQ QRTAANTTKK RAMPNQVIRR GWLTINISIM KGGSKDYWFV
     LTAESLSWYK DEEEKEKKFM LPLDNLKLRD LEKGFMSSKH VFAIFNTEQR NVYKDLRQIE
     LACDTQEDVD SWKASFLRAG VYPEKDQQQN EDAMSSSDTV SMDPQLERQV ETIRNLVDSY
     ISIVNKSIRD LMPKTIMHLM INNTKDFIHS ELLAYLYSCG DQGSLMEESA EQAQRRDEML
     RMYHALKEAL VIIGDISTTT ISTPMPPPVD DTWIAKEPSP PASRPLTSTT VPPNRPPAVR
     GSTPGPPPLN PSPAFGAPPV PSRPGPQGPY DTNSSVPLIP SRPARVPPAL PPGVPSRRPP
     AAPNRPTIIR PSEPSLLD
//