ID A0A3Q2CJV8_CYPVA Unreviewed; 830 AA.
AC A0A3Q2CJV8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSCVAP00000005482.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000005482.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000005482.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_015228938.1; XM_015373452.1.
DR AlphaFoldDB; A0A3Q2CJV8; -.
DR Ensembl; ENSCVAT00000006601.1; ENSCVAP00000005482.1; ENSCVAG00000006867.1.
DR GeneID; 107083901; -.
DR KEGG; cvg:107083901; -.
DR GeneTree; ENSGT00940000163991; -.
DR OMA; CKINISE; -.
DR OrthoDB; 4022492at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 565..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..816
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 566..830
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 830 AA; 92037 MW; 9C25F8E075217CBD CRC64;
MALPMNCVLQ GTSRLPAFST DGEYIIGGVF SIHYKELTKI HNYTTVPEPP TCTGSINSRE
LRFCRAMIFA IEEINNSTEL LPGIRLGYQI HDSCASVPMS MHVALQLSNG QDPVFQTGNN
CSKSGLVMGV IGESGSTPSI SISRIFGPFN IPLVSHFATC ACLSDKREYP TFFRTIPSDH
YQANAMAKLV KHFGWSWIGA IHSDSDYGRN GMASFLEAAH REGICVEYIE SFYRTDPYKI
RIVADVIRRS TSVVVVAFTA AGDMKFLLEE LNHNHPPPRQ WIGSEGWVTD RQLMRFSFCA
GAIGVAIQQS VIPGFGDFLL NLSPSKVAAS SVLTEFWEDV FSCSWTKSAS SKKKLCQGTE
DLKKIKVPYT EMSTFRITNM VYKAVYAIAH AIHNAVCYKT NFTIHCKKQT KLDLIQTFTE
LKKVNFTRNG YHVSFDANGD PVAAYDVVNW QISDSGIIEP VNVGYYDASL PKGQEFHINR
NLSWFDGGSQ VPVSVCSKSC APGTRKVLQK GKPICCYDCI PCAEGEISNM TDSLECIPCS
KEFWPNAGND ECFPKQVEFL SFDDLLSVIL AAFSVSGACM AIITTVVFFH YRTTPIVRAN
NSELSFLLLF SLTLCFLCSL TFIGAPSEWS CVLRHTAFGI TFVLCISCVL GKTIVVLMAF
KATLPGNNTM KWFGPPQQRL TVAGVTFIQV IICTIWLVVS PPFPMKNLHT YKEKIILECA
LGSAVGFWAV LGYIGLLAVF CFVLAALARK LPDNFNEAKL ITFSMLIFCA VWITFIPAYV
SSPGKYTVAV EIFAILSSSF GLMLCIFAPK CFIILYQPEK NTKKHLMNKY
//
