ID   A0A3Q2CLA5_CYPVA        Unreviewed;       665 AA.
AC   A0A3Q2CLA5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=SIX homeobox 4 {ECO:0000313|Ensembl:ENSCVAP00000006094.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000006094.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000006094.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC       ECO:0000256|RuleBase:RU000682}.
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DR   AlphaFoldDB; A0A3Q2CLA5; -.
DR   Ensembl; ENSCVAT00000005569.1; ENSCVAP00000006094.1; ENSCVAG00000007591.1.
DR   GeneTree; ENSGT00940000165916; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR031701; SIX1_SD.
DR   PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR   PANTHER; PTHR10390:SF64; HOMEOBOX PROTEIN SIX4.1-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF16878; SIX1_SD; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          203..254
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        205..255
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          244..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..565
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..278
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..505
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        528..565
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   665 AA;  71204 MW;  0DD6C7239C873812 CRC64;
     SVCDSTREGS NKKKKKMSSS SSGEVTAVND IKRENVKEVD TRESIKLVAL DAVELSMERT
     APNADAVRTE LLVSAASSLA FSPEQVACVC EALQQGGNVD RLARFLWSLP QSDLLRGNES
     ILKAQALVAF HQARYQELYS ILENHSFSPS NHTFLQELWY KARYTEAEKA RGRPLGAVDK
     YRIRRKYPLP RTIWDGEETV YCFKERSRNA LKDLYNQNRY PSPAEKRNLA KITGLSLTQV
     SNWFKNRRQR DRNPSEAQSK SESDGNHSTE DESSKGQEEL SPRPLSNSSD GVINHGSLPA
     QTGALDGGVV IQQIGDIKMS TGSGGGGVYN GSLAANNTSP AVFHNGGSSY LHSPGNILFN
     GLNLGIQPLA FNPLRPPSGV LLGGSSALHY SSYTGCVNGS EVKLEGVHTM ADQNGGSSVL
     TFSSPSGSLQ LGGYSLVQVP SGVPDSDGSS LLNTDVGLPP LQLPSASSSS TITQQGSMSL
     NNAVVSSSSQ DSFQPQDNMS NQTPIKKEPL DGGIYSSYHG GLHLDPSGQI SYTGSDSGHI
     SSSHGTTSTT DVTPISSSSS EPEVYTTLTN STPLMAQTDP DAHHHLQPAE FLGTHEVHRG
     APSSHLLGPG MNSDYMNISE SKSDISGPGG MNEMVRAMCG ELEAAEGKEL AKLQTVQMDE
     DMSDL
//