ID A0A3Q2CNS1_CYPVA Unreviewed; 442 AA.
AC A0A3Q2CNS1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=E2F transcription factor 3 {ECO:0000313|Ensembl:ENSCVAP00000007048.1};
GN Name=E2F3 {ECO:0000313|Ensembl:ENSCVAP00000007048.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000007048.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000007048.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; XP_015239394.1; XM_015383908.1.
DR AlphaFoldDB; A0A3Q2CNS1; -.
DR STRING; 28743.ENSCVAP00000007048; -.
DR Ensembl; ENSCVAT00000003960.1; ENSCVAP00000007048.1; ENSCVAG00000008651.1.
DR GeneID; 107090496; -.
DR KEGG; cvg:107090496; -.
DR CTD; 1871; -.
DR GeneTree; ENSGT00940000155115; -.
DR OMA; WMGCNLS; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF44; TRANSCRIPTION FACTOR E2F3; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 144..209
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 77..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 215..242
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 96..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 48103 MW; 9434E9FE2DAF2CB1 CRC64;
MRRGISSAPD KVILTGVGGS SLDNNLILTA LSDRLNPGQS NTTYIQIITT PPPCNVTQTS
NVCLSEPQVN SIYTTPQQAA ANGTGQRPSL GRPPAKRRLA LDDSDHQYQS EPAKTPRGRG
GAAAANGTRL KTPRTPKSPP EKTRYDTSLG LLTKKFVDLL AQSSDGVLDL NLAAETLQVQ
KRRLYDITNV LEGIHLIKKK SKNNIQWMGC SLLEVEGALS QRQNLTAEVS ALGEEEQRLE
QLIQRCSLDI RHMSELPGNQ KYAYITYQDI KQLRSLRDQT VIVVKAPTDT KLEVPDPDES
LSIHLTSTKG PIEVLLCPDE ENEISPVKNG STDINGNSPF LKVVQDSHCT TTSPSNFLSP
PTSSSAVSVT TLSPISSPYT SLLQQTEDQV HSSQGPFLNL VPPILEDDYL LGLEDDQGIS
DLFDACDFDK MPSLGLDDLL CS
//
