ID A0A3Q2CPA0_CYPVA Unreviewed; 840 AA.
AC A0A3Q2CPA0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000007253.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000007253.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00029431}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00029431}. Cytoplasmic vesicle, secretory
CC vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00004644};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004644}. Melanosome
CC {ECO:0000256|ARBA:ARBA00004223}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR RefSeq; XP_015234810.1; XM_015379324.1.
DR AlphaFoldDB; A0A3Q2CPA0; -.
DR STRING; 28743.ENSCVAP00000007253; -.
DR Ensembl; ENSCVAT00000003622.1; ENSCVAP00000007253.1; ENSCVAG00000008947.1.
DR GeneID; 107087643; -.
DR GeneTree; ENSGT00950000182881; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF68; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 1; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 401..425
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 445..464
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 542..560
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 572..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 636..656
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 744..762
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 774..796
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 94..121
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 840 AA; 95565 MW; 4178783634B9F486 CRC64;
MGEMFRSEEM TLAQLFLQSE AAYCCVSELG ELGMVQFRDL NPDVNVFQRK FVNEVRRCEE
MDRKLRFVEK EIKKASIPMV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
NFLELTELKH ILHRTQQFFD EMEDPNLLEE SSALMEGSEG GRGAPLRLGF VAGVISRERI
PTFERMLWRV CRGNVFLRKA EIEDPLEDPT TGDQVHKSVF IIFFQGDQLK NRVKKICEGF
RASLYPCPET PQERKEMLAG VNSRIDDLQM VLNQTEDHRQ RVLQAASKTM RVWFVKVRKM
KAIYHTLNLC NIDVTQKCLI AEVWCPVSDL DSIQFALRRG TERSGSTVPS ILNRMQTKQT
PPTFNKTNKF TSGFQNIVDA YGIGNYREIN PAPYTIITFP FLFAVMFGDM GHGLLMTCAA
LYLVLRESRI LAQKSDNEMF NMVFAGRYII LLMGIFSVYT GIIYNDCFSK SLNMFGSGWS
VRPMFSTKGA NWTFETLEGN AVLQLDPAVP GVFNGPYPLG IDPIWNVATN KLTFLNSFKM
KMSVILGVIH MLFGVSLSLF NHLYFKKPLN IFLGFIPEIV FMFSLFGYLI LLVFYKWTAY
DALSSKDAPS LLIHFINMCL FNYNDPTNKP LYRGQMGIQV LLVLIALACV PCMLVVKTMV
LRRQHLWKKH LGTQKFGGVR VGNGPTEDEA GIMDHDQLSQ HSDEGDEHSE EEPFNFGDVA
VHQAIHTIEY CLGCISNTAS YLRLWALSLA HAQLSEVLWS MVMHLGLSSS SGGGFFGLSI
IFSAFAALTV AILLVMEGLS AFLHALRLHW VEFQNKFYTG QGFKFVPFSF ESILEGRFDD
//
