ID A0A3Q2CPS5_CYPVA Unreviewed; 1033 AA.
AC A0A3Q2CPS5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Zinc finger E-box-binding homeobox 2-like {ECO:0000313|Ensembl:ENSCVAP00000007442.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000007442.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000007442.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_015257711.1; XM_015402225.1.
DR AlphaFoldDB; A0A3Q2CPS5; -.
DR Ensembl; ENSCVAT00000003297.1; ENSCVAP00000007442.1; ENSCVAG00000009111.1.
DR GeneID; 107102790; -.
DR KEGG; cvg:107102790; -.
DR GeneTree; ENSGT00950000183208; -.
DR OMA; AHYANSQ; -.
DR OrthoDB; 4266655at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF28; ZINC FINGER E-BOX-BINDING HOMEOBOX 2; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 252..279
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 280..315
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 806..833
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 834..861
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 862..892
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..1009
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1033 AA; 115882 MW; 914112C833BE04F8 CRC64;
MTEESRGKRR KQANPKRNRV DTEQVSALGS EEDDEVGLWS LEPQDCHESP DKTSLTPSEV
AEEPGSPVHF TRPPGLSPGI RICWGQVESE APAEEDDTHA STEVEREQEP LRMYCKNSDS
QNHFEDLPHY EFVSQLRRDS VNSSAVYRQS SRHDELPPAI WSPGAQHCSP ESADENRSQQ
ACPFCQRMYW RGASLRDHVK YCQERERGHM VCPLCGYTAN HRSQMEQHLA LHNQIQDKNA
ISLDQSMETR KFKCLECGKA FKYKHHLKEH LRIHSGEKPY ECSNCKKRFS HSGSYSSHLS
SKKCLSGGGH VGGNMGSGHN GHSQSSYHNS LPTSPSAGGG RSSNDHSSLL ALQNQEGIRS
LGHLQTDSHQ HTLLDFHQSF PGTSDQASLW DRLPDLPLRS SIVKGTSLLP YLHSGTKFDQ
MLQEMLHRDV KIERDKEEVE ERRVIHNGRG FERKVSPDRR REVRSGEVQR GTFGMTCRWC
LQPFPNMAVL LQHEHSLCKM NRDVVEATES FRRKDLSSPP LFFSRSALHS ENTQPAEATN
GFSENRSPLQ NPRWQSVPQQ LLEARPSPPP RPDALSSRMY LSSQDKGSPS HLSPRMSSPR
GRKRVPSSGF NSPVCLEVTG GPPDASPPQK EPRSPWSAQN EPLDLSLPKQ LSEPKGRNTT
LNGISGREVQ REVRTQQLSR PSPTSHLPLQ QFPILSSSGA PVFPASVFNG FNIFSQSGVG
LSLHEGLMQT PYSQAALSPR FLSPMAYMME ANAEAVLKKI YEERQSFMGE VLNRSALDYL
SITDEGFEGE GGPGRKRLKK TEEGLYACDI CDKTFQKSSS LLRHKYEHTG KRPHECKICN
KAFKHKHHLI EHSRLHSGEK PYQCDKCGKR FSHSGSYSQH MNHRYAYCSK DQDPDQDQEE
MPLTPGAGSS LVGSLGEDKS LSVDDPLMTH SFLSDSSLDG APDALKESEE KEERVQKIHK
GLLEVTEDLR SSPNGGSLTD GSNLRNKLSN CESGNHINKT ENQMWGRDTP DQNGGLDKCE
MNMELTELPT III
//
