ID A0A3Q2CPV9_CYPVA Unreviewed; 857 AA.
AC A0A3Q2CPV9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK1 {ECO:0000313|Ensembl:ENSCVAP00000007591.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000007591.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000007591.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR RefSeq; XP_015247185.1; XM_015391699.1.
DR AlphaFoldDB; A0A3Q2CPV9; -.
DR Ensembl; ENSCVAT00000003052.1; ENSCVAP00000007591.1; ENSCVAG00000009255.1.
DR GeneID; 107095563; -.
DR KEGG; cvg:107095563; -.
DR GeneTree; ENSGT00940000156253; -.
DR OMA; TMDMELF; -.
DR OrthoDB; 511851at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF36; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 554..573
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 630..652
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 811..835
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 424..792
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 434..498
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 857 AA; 96933 MW; 748BB91B7246208C CRC64;
MTMVKRTGLV FSLVYFMGWL WLTSQQVLRI GGIFETLENE PISVEELAFK FAVTNINRNR
TLMPNTTLTY DIQRINLFDS FEASRRACDQ LALGVGAVFG PSHSSSVSAV QSICNALEVP
HIQTRWKHPS VDNKDSFYIN LHPEYTSISR AVLDIVQFYK WKAVTVVYED ATGLIRLQEL
IKAPSRYTIK IKIRQLPLGS KDARPLLKEM KKGKEFFVIF DCSYQTSADV LKQIMSMGMM
TEYYHYFFTT LDLFALDLEP YRYSGVNMTG FRLLNVDNPK VASVLERWAM ERLQAPSKVE
TGMMEGMMTT EAALMYDAVY MVAAASQRTS QLTVSSLQCH RHKPWRFGSR FMNLLKDTQW
DGLTGQIAIN KTDGLRKEFD LDVISLKEDG LEKIGVWNSQ MGLNLTETSK DSSTNVTDSM
ANRTLIVTTI LENPYVMYKK SDKPLYGNDR FEGYCLDLLK ELSNILGFSY EVKLVSDGKY
GAQNDKGEWN GMVRELIDHV ADLAVAPLTI TYVREKVIDF SKPFMTLGIS ILYHKPNGTN
PGVFSFLNPL SPDIWMYVLL ACLGVSCVLF VIARFTPYEW YNPHPCNPDS DVVENNFTLI
NSVWFGVGAL MQQGSELMPK ALSTRIVGGI WWFFTLIIIS SYTANLAAFL TVERMDSPID
SADDLAKQTK IEYGAVRDGS TMTFFKKSKI STYEKMWAFM SSRKNTALVK NNREGIQRVL
TTDYALLMES TSIEYISQRN CNLTQIGGLI DSKGYGVGTP IGSPYRDKVT IAILQLQEEG
KLHMMKEKWW RGNGCPEEDS KEASALGVEN IGGIFIVLAA GLVLSVFVAI GEFIYKSRKN
LDIEEVSVGQ CEWHNKY
//
