ID   A0A3Q2CSP1_CYPVA        Unreviewed;      1101 AA.
AC   A0A3Q2CSP1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=UPF1 RNA helicase and ATPase {ECO:0000313|Ensembl:ENSCVAP00000008634.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000008634.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000008634.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC       {ECO:0000256|ARBA:ARBA00007913}.
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DR   AlphaFoldDB; A0A3Q2CSP1; -.
DR   Ensembl; ENSCVAT00000001289.1; ENSCVAP00000008634.1; ENSCVAG00000010561.1.
DR   GeneTree; ENSGT00940000157413; -.
DR   OMA; DTALECY; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   CDD; cd21407; 1B_UPF1-like; 1.
DR   CDD; cd18039; DEXXQc_UPF1; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   CDD; cd21400; ZBD_UPF1-like; 1.
DR   Gene3D; 2.40.30.230; -; 1.
DR   Gene3D; 6.10.140.1240; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR040812; UPF1_1B_dom.
DR   InterPro; IPR018999; UPF1_CH/ZBD.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF18141; UPF1_1B_dom; 1.
DR   Pfam; PF09416; UPF1_Zn_bind; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51997; UPF1_CH_RICH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT   DOMAIN          96..253
FT                   /note="Upf1"
FT                   /evidence="ECO:0000259|PROSITE:PS51997"
FT   REGION          43..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..136
FT                   /note="C3H"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          118..146
FT                   /note="CC/SHH/C"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          164..194
FT                   /note="C4"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          976..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1082..1101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1007..1068
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1101 AA;  121871 MW;  D103A6E55900EDAA CRC64;
     MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFDFTDFTL PSQTQTQGQT QSQLDGQING
     PDEGLHNGGM DDSVAKSSQL LGELNFEEDE EDTYYTKDLP IHACSYCGIH DPACVVYCNT
     SKKWFCNGRG NTSGSHIVNH MVRAKCKEVT LHKDGPLGET VLECYNCGCR NVFLLGFIPA
     KADSVVVLLC RQPCASQSSL KDINWDSSQW QPLIQDRCFL SWLVKIPSEQ EQLRARQITA
     QQINKLEELW KDNPGATLED LEKPGVDEEP QHVLLRYEDA YQYQNIFGPL VKLEADYDKK
     LKESQTQDNI TVRWDLGLNK KRIAYFTLPK TDSDMRLMQG DEICLRYKGD LAPLWKGIGH
     VIKVPDNYGD EIAIELRSSV GAPVEIPHNF QVDFVWKSTS FDRMQSALKT FAVDETSVSG
     YIYHKLLGHE VEDVTIKCQL PKRFTAPGLP DLNHSQVYAV KTVLQRPLSL IQGPPGTGKT
     VTSATIVYHL SRQGNGPVLV CAPSNIAVDQ LTEKIDKTGL KVVRLCAKSR EAIESPVSFL
     ALHNQISNMD SMPELQKLQQ LKDETGELSS ADEKRYRALK RTAERELLMN ADVICCTCVG
     AGDPRLAKMQ FRSILIDEST QATEPECMVP VVLGAKQLIL VGDHCQLGPV VMCKKAAKAG
     LSQSLFERLV VLGIRPIRLQ VQYRMHPALS AFPSNIFYEG SLQNGVTAAD RIKKGFDFQW
     PQPDKPMFFY VTQGQEEIAS SGTSYLNRTE AANVEKITTR LLKAGAKPDQ IGIITPYEGQ
     RSYLVQYMQF SGSLHTKLYQ QVEIASVDAF QGREKDFIIL SCVRANEHQG IGFLNDPRRL
     NVALTRAKYG VIIVGNPKAL SKQPLWNNLL NYYKEQKVLV EGPLNNLRES LMQFSKPRKL
     VNTINPGGRF MSTAMYDARE ALIPGSAYDR SSAAGRPSNM YFQTHDQIGM IGTGPGQMAA
     MNIPIPFNLV MPPMPPPSYL GQTNGPAPGR GAMKGKLGRG GRQRVRGSAH QGTSQGNGPN
     SQASQDGASQ SFSQGPLTQG YISMSQPSQM SQPGLSQPEL SQDSYLGDEF KSQIDVALSQ
     DSTYQGERAY QHGGVTGLSQ Y
//