ID   A0A3Q2CU04_CYPVA        Unreviewed;       719 AA.
AC   A0A3Q2CU04;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator like 3 {ECO:0000313|Ensembl:ENSCVAP00000009173.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000009173.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000009173.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_015248869.1; XM_015393383.1.
DR   AlphaFoldDB; A0A3Q2CU04; -.
DR   Ensembl; ENSCVAT00000000390.1; ENSCVAP00000009173.1; ENSCVAG00000011158.1.
DR   GeneID; 107096635; -.
DR   CTD; 100149956; -.
DR   GeneTree; ENSGT00940000165438; -.
DR   OMA; FHEPPQY; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00153; RA_RalGDS_like; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF372; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1-RELATED; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          55..174
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          213..484
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          609..697
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          180..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          511..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          556..595
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   719 AA;  80490 MW;  E3CA3D147DA93D21 CRC64;
     MGKWQLSMEP VQEWGEEEED GAIFGITLRR EPALSGSGSP DFSPAFGGVQ YHTVKVRRLK
     AATLERLVSH LLDPERREPD FIHVFLSTYR AFTSASSFIE LLFQRDESLS NLDNAVSLHS
     PALPVVRLWL EEYSSDFQEP PQYPALRLLC SHLRRRLCFR RLFQTAEALL KRLQAQDSSR
     SVSENQMESQ QCSPQSDEEL TSKQDKPNFM DFPAVDVAEQ LTRLDAELFV KVEPFHCLGC
     IWSQRDKKQN RNLAPTVRAT ICQFNAVTNC VITSLLCPSS PSPSLSSPFS SPSSTSTFLY
     PSSTPGSPHC SRFGPVHRAH IIEWWITVAQ ECRRLKNFSS LKAILSALQS NAVYRLKKTW
     AAVSRESMTV FDHLCETFPD ENCVLTNREV LVESLSCGIV PYLGTYLTVL TMLDTALTDT
     VEGCLINFEK RRREYEILSQ IKQLQGFCSH YRLSVNSCIT AWLQAQTLLT DQESYELSRE
     LEPPVDPCPN SPNSRSGRLL ATKLASLRTS HSDQISVSSS GSSGSDLEDL SIPQPSPFRL
     KLKSLPGSLH NVAEDFSMSS SSSPSLSGSS CSSSHPDLSS PSLTLSPDSS QSTCSPQGTL
     PLYNKQIADS CIIRVTVECV SNGNIYKSIL LTSQDHTPQV IQRALEKHNM EDFRSSDFGL
     YQLLNHGREL HIPDNANVFY AMCTSANYDF VLRQRWRSHG RQFGSFSSPG ARPRGRHIK
//