ID A0A3Q2CU17_CYPVA Unreviewed; 947 AA.
AC A0A3Q2CU17;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protocadherin alpha-C2-like {ECO:0000313|Ensembl:ENSCVAP00000009188.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000009188.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000009188.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q2CU17; -.
DR Ensembl; ENSCVAT00000000367.1; ENSCVAP00000009188.1; ENSCVAG00000011115.1.
DR GeneTree; ENSGT00940000160554; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF287; CADHERIN-RELATED NEURONAL RECEPTOR VARIABLE 1-RELATED; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..947
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018698091"
FT TRANSMEM 689..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..130
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 131..239
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 240..347
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 356..452
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 453..562
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 576..674
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 782..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..935
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 103186 MW; ACFCAF0E34AEA0E1 CRC64;
MGREGQRNTI WIHIWALLYF CGISTAQLSF SVYEEVDKGT VVGNLAKDLQ VSLNELEKRN
LQIISGTSKS YFDVDLKTGT LYVCNRIDRE ELCPNTAKCA LNIEAMLSNP VHLYRIEIQI
TDINDNAPSF REKEITLNVS ESSFSGERYL LPMANDADKG SNTVKGYKLS PNEYFSLDVQ
SGGQHSESSE LVLQKSLDRE KKAAIRLILT AFDGGKPAKS GTLTINVNVL DVNDNSPIFS
QSLYKAQVLE NTPSQSPVLT VSAADSDEGL NGEIEYSFIQ RGNLNPGAFF SINPETGEII
VIGKIDYEIN SAYDIRIQAR DKGTPSRSAH GKVLVEVIDV NDNIPEIVVT SVISPVKEDA
DTGTVVALVT VTDRDSGKNG LTSAKVVGLV PLKLKLNYKN YYSLTVDGPL DRESVSYYNV
TISAVDEGNP PLSSSTVIQV QISDVNDNPP LFSESVINVY IKENTAVGAT IAVITAHDPD
EADNAKVIYS LSGNFSKNIP ITSVLNINDQ TGDLICLQTF NYEEVKTFQF KVRANDSGVP
PLSSNVTVNV LILDENDNNP TILAPYSEHG SVNSETIPYT AEAGYFVAKI RAVDADSGYN
ALLSYHLSEP KGNNLFRIGT STGEIRTKRK MSDNDLKTHP LVVQVADNGE PSLSATVSME
VVVVENTADV QTQFRHVPLK NDNFSDLNLY LLIAIVSVSV IFLLSLISLI AVRCHRTDKS
FGRYSAPMIT THPDGSWSYS KATQQYDVCF SSDTLKSDVV VFPAPFPPVD AELISINGGD
TFTRTQTLPN KEKPKAPNSD WRYSASLRAG GVMQSSVHME ESSVMQGAQG VLVQNWPTAS
SAADGEGGEV SPPMGAGVDS NSWHFRYGPG GPGAPPQHLK PGEVPPEAFI IPGSPAIISI
RQNQGGEDDK SDFITFGKKE EAKKKKKKKK EKEKKDKKDK GKDDGDE
//
