ID   A0A3Q2CU62_CYPVA        Unreviewed;       849 AA.
AC   A0A3Q2CU62;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Protocadherin 2 alpha a 1 {ECO:0000313|Ensembl:ENSCVAP00000009306.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000009306.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000009306.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2CU62; -.
DR   Ensembl; ENSCVAT00000000165.1; ENSCVAP00000009306.1; ENSCVAG00000011254.1.
DR   GeneTree; ENSGT00940000165118; -.
DR   OMA; LEMHQVI; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF241; PROTOCADHERIN1-ALPHA-AV1; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        697..722
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        807..828
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          30..136
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          137..245
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          246..353
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          354..459
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          460..571
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          586..699
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   849 AA;  94834 MW;  863157D042BF65DF CRC64;
     MELMEMKRRW MDVLFSFCLF FLIVTKFEGI SAQIRYSIQE ELRSGTAVGN VAKDLALDLG
     KLRERNLRVI SGTKQDLFKV NSRDGVLSIN QRIDREELCA KTVPCITNLK VVVENPLEMH
     QIIIEILDVN DNSPKFPEEN YAMEVLESAV IGTRFQVEGA HDLDVGINSI HSYKMNHNQY
     FQLDTEDFGE EGKVPFLVLQ RPLDREQTPQ HWMLLTATDG GKPPKSGTMN ITIKLSDIND
     NSPVCDQQKY VVTITENAPV GTFLLAINAS DSDEGLNGMI EYSLRSKHPG PTSDLFDLNS
     ETGKLTVKGQ LNYEDRQIYE LKVLAADKGS VSLSTQCIVV VKVEDINDNP PEIEITSLSS
     RIREDAAPGT VVALMGVTDL DSGVNGQVVC SLSDDIPFDL KPSPDGQSYS LITKDYLDKE
     NTHMYNIKIT AKDLGSPSLS SIKLIQVDVL DMNDNRPLFT ESPYSFYVHE NNKAGLPVFS
     VTATDADEGE NAAVSYFLDR KSTGSSLTSF LNINEADGTV SALKSFDFES LKILKTFQFK
     VIATDSGTPS LSSNVTVNVF ILDQNDNTPV ILYPVSSNGS AEGVEEIPRN VNAGHLVTKV
     RAYDADIGYN GWLLFSLQEV TDHSLFGLDR YTGQIRTLRS FTETDEAEHK LVILVKDNGN
     VSLSATATVI VKLVEPKEAF SASDDKRATK NEEDNNMIFY LIITLGSVSL LFIISIIILI
     AMQCSKTTDY SSKYLQETNY DGTLCHSIQY RSGDKRYMLV GPRMSIGSTI VPGSHANTLV
     LPDRRKTSIE VRIYPLCFFS TRCCNSFIIY LFFFCGTEMY IFFCYFLDVL SDNFRKCKGR
     HQCYYSQCN
//