ID A0A3Q2CU81_CYPVA Unreviewed; 808 AA.
AC A0A3Q2CU81;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Disintegrin and metalloproteinase domain-containing protein 17-like {ECO:0000313|Ensembl:ENSCVAP00000009229.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000009229.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000009229.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR AlphaFoldDB; A0A3Q2CU81; -.
DR Ensembl; ENSCVAT00000000292.1; ENSCVAP00000009229.1; ENSCVAG00000011267.1.
DR GeneTree; ENSGT00940000155443; -.
DR OMA; NTTWNSE; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd14246; ADAM17_MPD; 1.
DR CDD; cd04270; ZnMc_TACE_like; 1.
DR Gene3D; 4.10.70.30; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR034025; ADAM10_ADAM17.
DR InterPro; IPR032029; ADAM17_MPD.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR PANTHER; PTHR45702:SF7; ADAM METALLOPEPTIDASE DOMAIN 17A ISOFORM X1; 1.
DR PANTHER; PTHR45702; ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER; 1.
DR Pfam; PF16698; ADAM17_MPD; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF13574; Reprolysin_2; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT TRANSMEM 633..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..436
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 437..525
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT REGION 717..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 368
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 367
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 371
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 377
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 808 AA; 89991 MW; 3BDF916B836E9853 CRC64;
MEAGFCSLFP ETLSSILSEY EVLPVSGFQL HSVRKRDVHS ESHLERLVSF RALQRDFKLY
LTTNTELFTD NFKAVFVDKN GKEEKYDVSL QNYFTGHVVG EAHSRVQAHI DGDEFSAHIL
TDETEYNIEP LWRFTDSPID GRLLVYRSQD IRNLSRIASP EVCGYIHAEA EDLFPEAARS
ESLHRVKRQA HDHRKNTCPL LLVADYRFFK QMGRSQESIT LNYLIELIDR VDDIYRNTTW
NNEFKDYGVQ IQQRPPGMSG AGWAHYNMEN SPVAGEEVWE VKKLLEQFSS DIAENASTVC
LAHLFTYQDF DKGTLGLAYV APPRNTPLAY YPSHSAKKPS YLNTGLTSTK NYGKTILTKE
ADLVTTHELG HNFGAEHDPD NLLNCAPSDD EGGKFVMYPI AVSGDHVNNK RFSDCSKASV
GKSLQLKAPM CFKERNSKVC GNSRVEEGED CDPGLLHLND DLCCSPECKF RENVKCSDRN
SPCCKNCQYQ QAGTKCQEPI SATCKGMSFC TGNSSQCPPP ENAMDDTICV DNGRCLKGEC
KPFCEAIEKL QSCACNETSD SCKVCCRKHG ICSPFTYPDG TFLYLRKGKP CTVGFCDGNG
KCMKQVQDVI ERLWDFIDKL DINTFGKFLA DNIVGSVVVF SLIFWIPLSI LVYCVVRSFK
FFSSPAVFAP QTQDILSNPE SAPVRIVKHS QPPFAARAAP SSQPLLLQSQ ARSLTPAAAC
SSTTTQDPGP SYAANQDSAG DLRMATIPED TSSDSHLVEE GLSGDFTTAG ASSSATKSSF
EDLTGQNPSR ERRRLKRQEC LDSKETEC
//
