ID   A0A3Q2CWZ8_CYPVA        Unreviewed;       926 AA.
AC   A0A3Q2CWZ8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000010289.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000010289.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC       {ECO:0000256|ARBA:ARBA00004201}.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC       {ECO:0000256|ARBA:ARBA00005601}.
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DR   STRING; 28743.ENSCVAP00000010289; -.
DR   Ensembl; ENSCVAT00000016946.1; ENSCVAP00000010289.1; ENSCVAG00000012443.1.
DR   GeneTree; ENSGT00940000156024; -.
DR   OMA; FMDYQND; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0032574; F:5'-3' RNA helicase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR   CDD; cd18038; DEXXQc_Helz-like; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR049080; MOV-10-like_beta-barrel.
DR   InterPro; IPR026122; MOV-10/SDE3_DEXXQ/H-box.
DR   InterPro; IPR049079; Mov-10_helical.
DR   InterPro; IPR049077; MOV-10_Ig-like.
DR   InterPro; IPR049075; MOV-10_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF537; HELICASE MOV-10; 1.
DR   Pfam; PF13086; AAA_11; 2.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF21634; MOV-10_beta-barrel; 1.
DR   Pfam; PF21635; Mov-10_helical; 1.
DR   Pfam; PF21633; MOV-10_Ig-like; 1.
DR   Pfam; PF21632; MOV-10_N; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          10..74
FT                   /note="Helicase MOV-10 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21632"
FT   DOMAIN          98..214
FT                   /note="Helicase MOV-10 Ig-like"
FT                   /evidence="ECO:0000259|Pfam:PF21633"
FT   DOMAIN          265..330
FT                   /note="Helicase MOV-10 helical"
FT                   /evidence="ECO:0000259|Pfam:PF21635"
FT   DOMAIN          337..415
FT                   /note="Helicase MOV-10-like beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF21634"
FT   DOMAIN          468..551
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          577..652
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          723..869
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
SQ   SEQUENCE   926 AA;  105473 MW;  468743DCB7FA532D CRC64;
     MVKRSVSSLV QIGMDFFEFL NETKRTSITD RLQLRDIYNN EFRNPGIKDP NFGSVIYALK
     VCKMVKRRQD NIKFTPKVTV QLFSNLCSLL DLRYLSMLLS DKHGISITSD CPFENGKLVL
     CYTVKLNVEN TGDQPLYFTY YTPLHWLRCL TLRDEKRVTR LQPLLLNPGD SYEVEVSFQC
     SLVGFFPATL AFEFKPDLEP TTAAFHIVRI IEAQCITDLG LELAPIAPFK PRCLPDWIPE
     PDCKIEDGQP PERLAVMQLE NVVHLKKYPT PPYMNDLIQL LRKPTHPSRN FLANEKSHLL
     ERPLCWDNYT EKFQLLLYLE ELQMVFDIRR YNIPNDDRKH AELARDTTNR KLLVLEVPGV
     SENRPSVLRG DSLLMYPQGE KGVKYRGYVH GVQLDSIRLG FYFSFIEGIK FNVEFTINRL
     LVHLQHRAAE LARSHKLRSV LFPVEPTFSC GKPDLPKLKL FDYQLEKNPE QYQAVQHIVA
     GSSRPAPYLV FGPPGTGKTV TVVEAIKQIE KTQTSCHILA CAPSNSAADL LCTKIREHVD
     ARNVYRIYAR NRDPKLVPEQ LKACSNLEGD SYRFPPKEKL MEYKIVVTTL LTAGRLVSGD
     IPSGHFTHVF VDEAGHAVET ECLVPLAGLL DAETGQLVLA GDPKQLGPIL RSPFALKYGM
     GVSLLERLMT DFPLYQKNEV TQIVWKEMLF FIFIFLLKKV LASLSGLPSD LPWGXFLHLF
     QGFPVIFHGV KGLETRESSS PSFFNVAEIE VLMEYVKKLF QTQGKKGLAK IAPKDIGIIA
     PYRKQVQKIR KALEKVGKDL KVTDMGDLKV GSVEEFQGQE RRVILVSTVR SSPRYFDIDK
     NFSLGFVKNE KRFNVAVTRA KALLIVVGNP LVLNADSTWA RFIEYCKEEG GYEGFTHAEE
     DEGEIVARLL DHFRDEDLNR FAKPAL
//